CNGNGE JOHN MCMURRY CHAPTER 22 Carbohydrate Metabolism T H IR D E DI TION Organic Chemistry with Biological applications
CHAPTER 22 Carbohydrate Metabolism
Carbohydrates Carbohydrates The chemical intermediaries by which carbon atoms from CO2 are incorporated into growing organisms Means by which solar energy is stored and used to support life The biological starting point Metabolism is intimately interconnected with the metabolism of all other biomolecules The catabolism of glucose is called the backbone of all metabolic pathways Starch H20 CH2OH HSCoA c02 HO Citric Glycolysis 2 acid →2c02 HO- H3C SCoA cycle OH OH a-Glucose Pyruvate Acetyl CoA LeamingAll Pighis Peservd
Carbohydrates ▪ The chemical intermediaries by which carbon atoms from CO2 are incorporated into growing organisms ▪ Means by which solar energy is stored and used to support life ▪ The biological starting point ▪ Metabolism is intimately interconnected with the metabolism of all other biomolecules ▪ The catabolism of glucose is called the backbone of all metabolic pathways Carbohydrates
22-1 Hydrolysis of Complex Carbohydrates Carbohydrate found in food is mostly starch A glucose polymer Monosaccharide units are linked by a-(1-4)glycoside bonds Consists of two main fractions 1.Amylose Makes up 20%of starch by mass A linear polymer of several hundred a-(1-4)-linked glucose units 2.Amylopectin Makes up 80%of starch by mass A branched polymer of up to 5000 glucose units with a- (1-6)branches about every 25 units
Carbohydrate found in food is mostly starch ▪ A glucose polymer ▪ Monosaccharide units are linked by a-(1→4) glycoside bonds ▪ Consists of two main fractions 1. Amylose ▪ Makes up 20% of starch by mass ▪ A linear polymer of several hundred a-(1→4)-linked glucose units 2. Amylopectin ▪ Makes up 80% of starch by mass ▪ A branched polymer of up to 5000 glucose units with a- (1→6) branches about every 25 units 22-1Hydrolysis of Complex Carbohydrates
Hydrolysis of Complex Carbohydrates The structure of amylopectin,the major carbohydrate found in starch CH2OH HO- CH2OH OH 0← a-(1-6)glycoside branch HO 6 H2C OH a-(1-4)glycoside link HO 6 CH2OH 6 CH2OH HO Amylopectin:a-(1-4)links with a-(1-6)branches
The structure of amylopectin, the major carbohydrate found in starch Hydrolysis of Complex Carbohydrates
Hydrolysis of Complex Carbohydrates Digestion of starches Begins in the mouth Many of the internal(1-4)glycoside links are randomly hydrolyzed by a-amylase,a glycosidase Continues in the small intestines Gives a mixture of disaccharide maltose,trisaccharide maltotriose,and small oligosaccharides called limit dextrins, which contain (1-6)branches Final processing in the intestinal mucosa by additional glycosidases Yields glucose which is absorbed by the intestine and transported through the bloodstream
Digestion of starches ▪ Begins in the mouth ▪ Many of the internal (1→4) glycoside links are randomly hydrolyzed by a-amylase, a glycosidase ▪ Continues in the small intestines ▪ Gives a mixture of disaccharide maltose, trisaccharide maltotriose, and small oligosaccharides called limit dextrins, which contain (1→6) branches ▪ Final processing in the intestinal mucosa by additional glycosidases ▪ Yields glucose which is absorbed by the intestine and transported through the bloodstream Hydrolysis of Complex Carbohydrates