第二部分有机化学反应 第六章有机化学反应理论 第七章有机化学反应机制及研究方法
第二部分 有机化学反应 第六章 有机化学反应理论 第七章 有机化学反应机制及研究方法
有机反应总论的主要问题 ●热力学 Thermodynamics 动力学 Kinetics 反应机制 Reaction Mechanism ●反应的方向、活性与选择性 反应活泼中间体 Active Intermediates ●有机反应机制的研究方法
有机反应总论的主要问题 热力学 Thermodynamics 动力学 Kinetics 反应机制 Reaction Mechanism 反应的方向、活性与选择性 反应活泼中间体Active Intermediates 有机反应机制的研究方法
Thermodynamics e Question: 1.In what direction does the reaction proceed? 2 Does the reaction release or absorb heat? ● Thermodynamics-热力学问题 9 Equilibria, Energy changes 反应方向、平衡、能量变化
Thermodynamics Question: 1. In what direction does the reaction proceed? 2. Does the reaction release or absorb heat? Thermodynamics——热力学问题 ----- Equilibria, Energy changes ——反应方向、平衡、能量变化
Thermodynamics For the generalized reaction aa t bB cct dD e we have IProducts ICTIDI 4 Reactants「A1「B巾
Thermodynamics For the generalized reaction: we have aA + bB c C + d D Ke q = [Products] [Reactants] = [ C ]c [ D ]d [ A ]a [ B ]b
Thermodynamics ● ree Energy自由能)AG9=- REInKe ●When△G0 1s negative, the reaction is exergonic(放能的), has a favorable equilibrium constant, and can occur spontaneously. When AGo is positive the reaction is endergonic(吸能的), has an unfavorable equilibrium constant and cannot occur spontaneous ly
Thermodynamics Free Energy（自由能）△G 0 = - RTlnKeq When △G 0 is negative, the reaction is exergonic （ 放能的 ） , has a favorable equilibrium constant, and can occur spontaneously. When △G 0 is positive, the reaction is endergonic （ 吸 能 的 ） , has an unfavorable equilibrium constant, and cannot occur spontaneously