NADH的紫外吸收 1.0 Oxidized 0.8 (NADT) 0.6 0.4 Reduced (NADH) 0.2 0.0 220240260280300320340360380 Wavelength(nm) (b)
NAD+/NADH的紫外吸收
以NAD和NADP Stereochemical specificity for nicotinamide Enzyme Coenzyme ring(A or B) Isocitrate dehydrogenase NAD A a-Ketoglutarate dehydrogenase NAD+ B Glucose b-pi hosphate dehydrogenase NADP B Malate dehydrogenase NAD Glutamate dehydrogenase NAD or NADP+ B Glyceraldehyde 3-phosphate dehydrogenase NAD B Lactate dehydrogenase NAD A Alcohol dehydrogenase NAD A
以NAD+和NADP+为 辅酶的脱氢酶
迟缓、发育停滞、脂 肪肝以及包括溃疡在内的胃肠紊乱 。 尼克酰胺能抑制胰腺癌的发展, 给仓鼠注射致胰腺癌物后,给以尼 克酰胺治疗,发现癌症的发展受到 卯制。尼克酰胺与叶酸一样能刺激 受损的DNA的修复
烟酸的作用 •缺乏：生长迟缓、发育停滞、脂 肪肝以及包括溃疡在内的胃肠紊乱 --黑舌病。 •尼克酰胺能抑制胰腺癌的发展， 给仓鼠注射致胰腺癌物后，给以尼 克酰胺治疗，发现癌症的发展受到 抑制。尼克酰胺与叶酸一样能刺激 受损的DNA的修复
椭病【 Pellagra】 Early stages Anorexia(厌食) Indigestion(消化不良) Muscle weakness(肌无力) Reddened skin(红皮肤) Rough skin(皮肤粗糙) Advanced stages °3 D's of pellagra: Dermatitis(皮炎), Diarrhea(腹泻), Dementia(痴呆)
糙皮病【Pellagra】 • Early stages: • Anorexia（厌食） • Indigestion（消化不良） • Muscle weakness（肌无力） • Reddened skin（红皮肤） • Rough skin（皮肤粗糙） • Advanced stages • 3 D’s of pellagra: Dermatitis（皮炎）, Diarrhea（腹泻）, Dementia（痴呆）
Tryptophan can substitute for niacin: 60 mg of tryptophan is equivalent to 1 mg of niacin; 60 gm of protein contains 600 mg of tryptophan which then represent 10 mg of niacin TRYPTOPHAN FORMYLKYNURENINE KYNURENINE 甲酰犬尿氨酸 血管紧张肽原酶 3-HYDROXYANTHRANILIC ACID 3-HYDROXYKYNURENINE 3羟基氨基苯甲酸 3羟基犬尿氨酸 B6-de pe ndent reac NICOTINIC ACID
Sparing Action of Tryptophan TRYPTOPHAN FORMYLKYNURENINE KYNURENINE 3-HYDROXYKYNURENINE 3-HYDROXYANTHRANILIC ACID NICOTINIC ACID B6-dependent reaction Tryptophan can substitute for niacin: 60 mg of tryptophan is equivalent to 1 mg of niacin; 60 gm of protein contains 600 mg of tryptophan which then represent 10 mg of niacin。 甲酰犬尿氨酸 血管紧张肽原酶 3-羟基犬尿氨酸 3-羟基氨基苯甲酸