Reaction with Nitrous acid 脂肪伯胺 RNH,HO→N=O H2 R-N三N 醇,烯烃的混合物 OH CH3(CH2)3OH CH3 CH2CHCH3 13% NaNO2/HCI(aq 25% CH3(CH2)3NH2 CH3(CH2)3CI CH3 CH2 CHCH3 25C 5% 3% H CH CH CHr,CH=CH CH 26% 3% 7% CH3CH2CH2CH2N2 Cr - -CH3CH2CH2CH2+ Rearrangement CH3CH2CHCH3
脂肪伯胺 e.g. CH3(CH2)3NH2 NaNO2 /HCl(aq.) 25 C o CH3(CH2)3OH CH3CH2CHCH3 OH CH3(CH2)3Cl CH3CH2CHCH3 Cl CH3CH2CH=CH2 CH3 C C CH3 H H CH3 C C CH3 H H 26% 3% 7% 5% 3% 13% 25% Reaction with Nitrous Acid -N2 Rearrangement RNH2 HO N=O R N N + H2O N2 + 醇, 烯烃的混合物 CH3CH2CH2CH2N2 + Cl - CH3CH2CH2CH2 + CH3CH2CHCH3
Reaction with Nitrous acid 仲胺 R Arner Ar-n-n=O HNO2 R R2NH R-N-N=O N亚硝基胺 黄色油状物,难溶于水和稀酸
仲胺 ArNHR or R2NH HNO2 Ar N N R O R N N R O N-亚硝基胺 黄色油状物，难溶于水和稀酸 Reaction with Nitrous Acid
Reaction with Nitrous acid 脂肪叔胺 Rrn t hno? ReHn NO2 成盐 芳香叔胺 hNO? (CH3)2N一 (CH3)2N -NO (CH3)2N CH HNO2(CH3hN NO 苯环上取代
脂肪叔胺 R3N + HNO2 R3HN + NO2 - 芳香叔胺 (CH3)2N HNO2 (CH3)2N CH3 HNO2 (CH3) 2N NO (CH3)2N CH3 NO 成盐 苯环上取代 Reaction with Nitrous Acid