置庆医科大学脑床学院裁来讲满 重庆医科大学临床学院教案及讲稿 课程名称传染病学年级2004级授课专业 留学生 教师袁喆职称 副牧授授课方式 大课示教学时4 题目章节Part3 Chapter3 Malaria 教材名称Lemology 作者 Chief Editor:Liu Zhengwen 出版社Xi'an Jiaotong University 版次 2004.1 教学目的要求 3 Features of】 alaria 6.Preventl of Malaria 教学难 1.Epidemic Process and The effect Factors. of Malaria 1.Definition Etiology 教学重点 4.Pathogenesis erential Diagnosis 外语 要求 English Language 教学 Classroom lectures and multimedia 1,15th Edition Mandell Douglas and Bennett's Principales and Practice of Infectious Diseasea Vol-2. 参考 2001 edited by Gerald LMandell,Jone E.Bennett,Raphael Dolin,publishing by Harcourt Ansia and 资料 Churchill Livingstone 2.4th Edition Kelley's Textbook of Internal Medicine 2004 edited by H.David Humes,publishing by Lippincott Williams&Wilkins Ine. 教学组长： 教研室主任： 年 日 制表时间：2004年8月 1
重庆医科大学临床学院教案讲稿 制表时间：2004 年 8 月 1 重庆医科大学临床学院教案及讲稿 课程名称 传染病学 年级 2004 级 授课专业 留学生 教 师 袁 喆 职称 副教授 授课方式 √大课 示教 学时 4 题目章节 Part 3 Chapter3 Malaria 教材名称 Lemology 作者 Chief Editor :Liu Zhengwen 出 版 社 Xi’an Jiaotong University 版次 2004 .11 教 学 目 的 要 求 1.Etiology 2.Epidemiology 3.Features of Malaria 4.Diagnosis of Malaria 5.Treatment of Malaria 6.Preventl of Malaria 教 学 难 点 1．Epidemic Process and The effect Factors。 2．Pathogenesis of Malaria。 教 学 重 点 1. Definition 2. Etiology 3.Epidemiology 4. Pathogenesis 5. Clinical manifestation of Epidemic cerebrospinal meningitis 6. Complications 7. Laboratory Findings 8. Diagnosis and Differential Diagnosis 9.Treatment of Epidemic cerebrospinal meningitis 外语 要求 English Language 教学 方法 手段 Classroom lectures and multimedia 参考 资料 1、15th Edition Mandell,Douglas and Bennett’s Principales and Practice of Infectious Diseasea.Vol-2, 2001 edited by Gerald L.Mandell,Jone E.Bennett,Raphael Dolin, publishing by Harcourt Ansia and Churchill Livingstone. 2、4th Edition Kelley’s Textbook of Internal Medicine 2004 edited by H.David Humes, publishing by Lippincott Williams & Wilkins Inc. 教研 室意 见 教学组长： 教研室主任： 年 月 日
置庆医科大学脑床半院载未讲满 Time arrangement 、Definition 15Min asitosis caused by plasmodia 0 there are an emia splenomegaly 二、Epidemiology 25Min Tachysporozoite Bradysporozoite Merozoite whole Two host. ediate hos mosquito-final host notes clinical symptoms:erythrocytic stage 辅助手段： relapse:exerythrocytic stage 同步播放 infectivity:sporozoite 多媒体课件 三、Epidemiology 20Min Source of infection Patient. paras 时间分配. Rou 见教学内容 blood transfusion to biting person Susceptibility universal susceptibility no-cross-immunity re-infection Epidemic features: sporadic or endemic,tropic or subtropic 四、Pathogenesis 20Min Mechanism ofattack P.Faciparam:produce microvascular disease magnitude ofthe parasitemia&age of patient no specific Ab or cell-mediated response Anemia -retiform RBC P.Falcipar um every RBC Prolifeation of mononuclear phagocvte 制表时间：2004年8月
重庆医科大学临床学院教案讲稿 制表时间：2004 年 8 月 2 Time arrangement 一、Definition 15Min Malaria is a parasitosis caused by plasmodia. It is transmitted to human by the bite of mosquito. Clinical feature: cyclic chill, high fever & profuse sweating. In chronic illness, there are anemia & splenomegaly. 二、Epidemiology 25Min Tachysporozoite Bradysporozoite Merozoite Sporozoite Parasitemia Tow period: human - whole asexual reproduction mosquito - sexual parasitic stage Two host: human - intermediate host mosquito - final host notes: clinical symptoms: erythrocytic stage relapse: exerythrocytic stage infectivity: sporozoite 三、Epidemiology 20Min Source of infection： Patient, parasite carrier Route of transmission female mosquito biting person blood transfusion Susceptibility: universal susceptibility no-cross-immunity re-infection Epidemic features: sporadic or endemic, tropic or subtropic 四、Pathogenesis 20Min Mechanism of attack P. Faciparam: produce microvascular disease magnitude of the parasitemia & age of patient no specific Ab or cell -mediated response Anemia: P. Vivax - retiform RBC P. Malariae - mature RBC P. Falciparum - every RBC Prolifeation of mononuclear phagocyte 辅助手段： 同步播放 多媒体课件 时间分配： 见教学内容
君庆医科大学脑床半院表来讲测 hepatomegaly enomegaly Cerebral edema congestion 五、Clinical manifestation 20Min Ihetiiht2430d tertian malaria:13~15 day malignant malaria:7~12 day Typical attack Chill:abrupt onset,shivering,pale face,cyanosis.Last 10 min or 1~2hr. High fever.T rise to 40oC with malaise,myalgia,thirsty.Last 2-6 Hr. 装ye Sings anemia splenomegaly hepatomegaly,ALTelevate Pemiciouse attack:cause by P.Falciparum bral malaria high fev er,headache,vomiting,convulsion delirum,respiratory failure Relapse:early relapse-<3m, later relapse->6m Malaria caused by transfusion incubation period:7~10 day no exerythrogenic phase,no relapse 六、Complications 20Min Black-water-fever: cause:I/inadequate G-6-PD 2/The toxin release by malarial parasite 3/Allergic reaction to anti-malarial /dark redor black urine Acute glom 七、Laboratory Findings 20Min Blood picture:decrease in RBC&Hb blood film for parasite serological examination 制表时间.2004年8月
重庆医科大学临床学院教案讲稿 制表时间：2004 年 8 月 3 hepatomegaly splenomegaly Cerebral edema & congestion 五、Clinical manifestation 20Min Incubation period: quartan malaria: 24-30 day tertian malaria: 13~15 day malignant malaria: 7~12 day Typical attack Chill: abrupt onset, shivering, pale face,cyanosis. Last 10 min or 1~2hr. High fever: T rise to 40oC with malaise, myalgia, thirsty. Last 2~6 Hr. Sweating: profuse sweating with restlessness regular 48 hr. or 72 hr. Cycle Sings anemia splenomegaly hepatomegaly, ALT elevate Perniciouse attack: cause by P. Falciparum cerebral malaria high fever, headache, vomiting, convulsion delirum, respiratory failure hyperpyrexia type T> 420C, convulsion, delirium Relapse: early relapse - <3m, later relapse - >6m Malaria caused by transfusion incubation period: 7~10 day no exerythrogenic phase, no relapse 六、Complications 20Min Black- water- fever: cause:1/inadequate G-6-PD 2/The toxin release by malarial parasite 3/Allergic reaction to anti-malarial drugs feature:1/chill & fever 2/dark red or black urine 3/severe hemolytic anemia Acute glomerulonephritis 七、Laboratory Findings 20Min Blood picture: decrease in RBC & Hb blood film for parasite serological examination
置庆医科大学床半院藏讲满 ELISA for P.antigen DNA hybridization 八、Diagnosis and Differential Diagnosis 10Min Epidemiological data endemic zone rosis 九、Treatment 10Min Anti-malarial drugs Chloroquine-susceptable infection chloroquine:1g/d,for 3 day.p.o. primaquine:for 8day,p.o. Chloroquine-resistant infection mefloguine: artemisinine ng/kg iv dr ese10 ng/kg iv0o吧ph2hr (3 day)+primaquine (8 day) 制表时间：2004年8月
重庆医科大学临床学院教案讲稿 制表时间：2004 年 8 月 4 ELISA for P. antigen DNA hybridization 八、Diagnosis and Differential Diagnosis 10Min Epidemiological data endemic zone blood transfusion Clinical manifestation Laboratory findings Diagnostic treatment: chloroqunine for 3 days Typhoid fever Septicemia Leptospirosis Encephalitis B 九、Treatment 10Min Anti-malarial drugs Chloroquine-susceptable infection chloroquine : 1g /d, for 3 day, p.o. primaquine: for 8day, p.o. Chloroquine-resistant infection mefloguine: artemisinine Pernicious attack Chloroquine: 10mg/kg iv drop in 4 hr. Then 5mg/kg, iv drop in 2 hr. Quinine: 500mg iv drop in 4 hr. Radical therapy Chloroquine (3 day) + primaquine ( 8 day)
君庆医科大学脑床半院表来讲测 Malaria is a parasitosis caused by plasmodia. It is transmitted to human by the bite of mosquito. Clinical feature:cyclic chill,high fever profuse sweating.In chronic illness, 小结 there are anemia splenomegaly. 1.Defination of Malaria 2、Clinical of Malaria 教案讲稿质量评价表 制表时间：2004年8月
重庆医科大学临床学院教案讲稿 制表时间：2004 年 8 月 5 小结 Malaria is a parasitosis caused by plasmodia. It is transmitted to human by the bite of mosquito. Clinical feature: cyclic chill, high fever & profuse sweating. In chronic illness, there are anemia & splenomegaly. 思考 题及 预习 1、 Defination of Malaria 2、Clinical of Malaria 3、Treatment of Malaria. 教案讲稿质量评价表