Antifungal Agents Fungi are plant-like, nonphotosynthetic eukaryotes growing either on colonies of single cells(yeasts)or in filamentous multicellular aggregetes(molds). Most fungi live as saprophytes in soil or on dead plant materials and are important in the mineralization of organic matter. There are 300,000 kinds of fungi, but only 270 of which produce disease in humans and animals. These fungi are divided into two sections according mycotic illnesses in huamns they produced. That is: shallow fungi, produces skin and hair infections, system fungi, produces visceral infetions. In recent year, the incidence of fungal infections has reached alarming proportions. This duo to a number of factors such as intensive uses of chemotherapies for bacterial infection and cancers. The number of systemic infections have especially increased, this has been true for large populations of immunocompromized patients as well as those
Antifungal Agents Fungi are plant-like, nonphotosynthetic eukaryotes growing either on colonies of single cells(yeasts) or in filamentous multicellular aggregetes(molds).Most fungi live as saprophytes in soil or on dead plant materials and are important in the mineralization of organic matter. There are 300,000 kinds of fungi, but only 270 of which produce disease in humans and animals. These fungi are divided into two sections according mycotic illnesses in huamns they produced. That is:shallow fungi, produces skin and hair infections, system fungi, produces visceral infetions. In recent year, the incidence of fungal infections has reached alarming proportions. This duo to a number of factors such as intensive uses of chemotherapies for bacterial infection and cancers. The number of systemic infections have especially increased, this has been true for large populations of immunocompromized patients as well as those
Suffering from various hematological malignancies, acquired immun deficiency syndrome(AlDs)and patients undergoing organ transplantation So, to develop a new antifungal agents is a very important work. 温暖来件下 面包上的希 旺&且殖
Suffering from various hematological malignancies , acquired immune deficiency syndrome(AIDS) and patients undergoing organ transplantation. So, to develop a new antifungal agents is a very important work
5.1 The classification of antifungal agents Polyenes Amphotericin)B Antimycotic antibiotics: Others (Griseofulvin) Fluorinated pyrimidines(fluorocytosine) Imidazoles (ketoconazole) Azoles Synthetic antifungal Triazoles fluoconazole) Agents: Allyamines (Terbinafine) Thioureas (Tolnafate) Others (Ciclopirox)
5.1 The classification of antifungal agents: Antimycotic antibiotics: Synthetic antifungal Agents: Polyenes ( Amphotericin) B Others (Griseofulvin) Fluorinated pyrimidines (Fluorocytosine) Azoles Imidazoles (ketoconazole) Triazoles (Fluoconazole) Allyamines (Terbinafine) Thioureas (Tolnafate) Others (Ciclopirox)
The classification according to the actions of drugs Acetyl-CoA Squalene Epoxidase +#Ally amines(Thiocarbamates) Lanoste rol ∥- Azoles Cytochrome 14 Demethy llanoster ol P450 Ergosterol +/ Polyenes (Mor phil ines) Cell membranes Griseofulvin DNA Cell nucles Flucytosine ∠-N ucleic ac d
Acetyl CoA Squalene Epoxidase Allyamines (Thiocarbamates) Lanosterol 14 Demethyllanosterol Cell membranes Ergosterol Cytochrome P 450 Azoles Polyenes (Morphilines) Cell nucles Grisofulvin Flucytosine DNA Nucleic acid The classification according to the actions of drugs
5.2 Antimycotic antibiotics 521 Amfotericin B(AMB)(两性霉素B) OH OH OH O HOOC' O OHOH OH oH O H CH NH OH AMB was marked in 1951s, is most commonly antibiotics used to treatment systemic fungal infections and is the only Polyene antibiotic antifungal agents for injection use
5.2 Antimycotic antibiotics 5.2.1 Ampotericin B(AMB)(两性霉素B) O O O OH H HOOC OH OH OH OH OH OH OH O O CH3 OH NH2 OH AMB was marked in 1951’s, is most commonly antibiotics used to treatment systemic fungal infections and is the only Polyene antibiotic antifungal agents for injection use