活性递增 OH 解痉挛 CO2R R Spasmolytic activity 500 CH3 8 C2Hs 12 300 C3Hz 24 250 C4Hg 98 CsH11 240 C6H13 410 50 0 C7H15 490 HCI C2 C3 C4 C5 C6 C7
活性递增 0 50 100 150 200 250 300 350 400 450 500 HC1 C2 C3 C4 C5 C6 OH CO2R R Spasmolytic activity CH3 8 C2H5 12 C3H7 24 C4H9 98 C5H11 240 C6H13 410 C7H15 490 C7 解痉挛
PAF-acether同系物的抗凝作用 1400 1200 1000 O-(CH2)n-CH3 800G 600 400G 200 0 35911151719 Chain length
PAF-acether 同系物的抗凝作用 O O O O-(CH2 )n-CH3 P O N + O - O 0 200 400 1200 600 800 1400 1000 3 5 9 11 15 17 19 Chain length
GABA拮抗剂与GABAA受体的亲和性 70 60 50 40 (CH2)n-CO2H 30 NH2 20 10 =1 n=2 n=3n=4 n=5
GABA拮抗剂与GABAA受体的亲和性 N N NH2 (CH2 )n-CO2H 0 10 20 60 30 40 70 50 n=1 n=2 n=3 n=4 n=5
Alternation:氨基喹啉类的抗疟活性 NH-(CH2)n-N(CH3)2 100 OCH3 40 Effect 20 10
Alternation: 氨基喹啉类的抗疟活性 N OCH3 NH-(CH2 )n-N(CH3 )2 0 20 40 60 80 100 4 5 6 7 8 9 10 ％ Effect n