Endiyne Antitumor Agents cycloaromatization HO diradical HO H abstraction
Endiyne Antitumor Agents HO cycloaromatization HO . . HO H abstraction diradical
CH; CO2H OH OCH; OH 0 OH Dynemycin A Antitumor antibiotic
N H O O OH OH OH CO2 H OCH3 CH3 O Dynemycin A Antitumor antibiotic
CH3 base: HO CH3 OCH3 NHCH3 HO NCS-chrom OH HO CH NHCH? HO HO
O O O O O CH3 HO OCH3 O O O NHCH3 HO HO CH3 base: O CH3 O OCH3 O O O NHCH3 HO HO CH3 O O O NCS-chrom OH
CH3 base: OCH3 H-base CH3 ⊕ NHCH: HO NCS-chrom OH HO CH3 NHCH HO HO
NCS-chrom O O O O O CH3 O OCH3 O O O NHCH3 HO HO CH3 H base: OH O O O O CH3 O OCH3 O O O NHCH3 HO HO CH3 H-base
CH3 CH3 H OCH3 NHCH3 OH HO CH3 Diradical inte rmediate unde rgoes H atom transfer with NHCH3 ribose backbone in DNA HO HO
OH O O O O CH3 O OCH3 O O O NHCH3 HO HO CH3 O CH3 O OCH3 O O O NHCH3 HO HO CH3 O O O OH . . Diradical intermediate undergoes H atom transfer with ribose backbone in DNA