Structure and Synthesis of Alcohols Biological Activity Nomenclature Preparation Reactions
Structure and Synthesis of Alcohols Biological Activity Nomenclature Preparation Reactions
Structure of Water and Methanol 0.96A 1.4A 0.96 日104.5 108.9 H water water water methyl alcohol methyl alcohol methyl alcohol o2013 Poarson Educe谢eni的 Oxygen is sp3 hybridized and tetrahedral. ·TheH-O-H angle in water is 104.5° ·TheC-O-H angle in methyl alcohol is 108.9°. 2013 Pearson Education,Inc Chapter 10 2
© 2013 Pearson Education, Inc. Chapter 10 2 Structure of Water and Methanol • Oxygen is sp3 hybridized and tetrahedral. • The H—O—H angle in water is 104.5°. • The C—O—H angle in methyl alcohol is 108.9°
Examples of Classifications CH3 QH CH;-CH-CH2OH CH一CH-CH2CH Primary alcohol Secondary alcohol CH3 OH CH3一 OH CH3 Tertiary alcohol Phenol
Examples of Classifications CH3 C CH3 CH3 * OH CH3 CH OH CH2CH3 * CH3 CH CH3 CH2OH * Primary alcohol Secondary alcohol OH Tertiary alcohol Phenol
Type Structure Examples H CH3 Primary alcohol OH CH3CH2-OH CH3CHCH2一OH CH2一OH ethanol 2-methyl-1-propanol benzyl alcohol CH3 R CH-OH H OH Secondary alcohol OH CH2 H CH3 HO 2-butanol cyclohexanol cholesterol R CH3 Ph CH Tertiary alcohol OH CH3-C-OH Ph一C一OH OH CH3 Ph 2-methyl-2-propanol triphenylmethanol 1-methylcyclopentanol OH OH OH Phenols OH CH3 HO phenol 3-methylphenol hydroquinone
Some Alcohols OH OH CH:CH2OH HO CHCH-NH2 CHCHNHCH3 CH; ethanol HO adrenaline (epinephrine) pseude phedrine QH HOCH2CHCH2OH glycerol HO cholesterol
Some Alcohols C H3C H2O H HO HO CHCH2NH2 OH adrenaline (epinephrine) ethanol CHCHNHCH3 OH CH3 pseudephedrine HO H H H cholesterol HOCH2CHCH2O H OH glycerol