Organic Chemistry with BiologicalApplications,3rEdition John McMurry Chapter 04 Organic compounds: cycloalkanes and their stereochemistry The chemistry of a given functional group is affected by being in a ring rather than an open chain. Cyclic molecules are so commonly encountered in most pharmaceuticals and in all classes of biomolecules. It's important to understand the consequences of cyclic structures
Chapter 04 Organic compounds ： cycloalkanes and their stereochemistry Organic Chemistry with Biological Applications, 3 rd Edition John McMurry The chemistry of a given functional group is affected by being in a ring rather than an open chain. Cyclic molecules are so commonly encountered in most pharmaceuticals and in all classes of biomolecules. It’s important to understand the consequences of cyclic structures
有额化学 Organic Chemistry with BiologicalApplications,3 Edition John McMurry Chapter 04 Organic compounds: cycloalkanes and their stereochemistry Homework:P86d:3.42a,b; P108:4.18a-d Key Notes Conformation;Stability;Ring Strainj Stereochemistry;a ee bonds
Chapter 04 Organic compounds ： cycloalkanes and their stereochemistry Organic Chemistry with Biological Applications, 3 rd Edition John McMurry Homework： P86d:3.42a,b; P108: 4.18a-d Key Notes Conformation; Stability; Ring Strain; Stereochemistry ; a & e bonds
Main Contents INaming alkanes of Bridged and spiro rings Conformations of cycloalkanes a &e bonds in cyclohexane Effects of alkyl groups on conformation Conformations of polvcvclic molecules A membrane channel protein that conducts Cl2 ions across cell membranes
Main Contents ◼Naming alkanes of Bridged and spiro rings ◼Conformations of cycloalkanes ◼ a & e bonds in cyclohexane ◼Effects of alkyl groups on conformation ◼Conformations of polycyclic molecules A membrane channel protein that conducts Cl2 ions across cell membranes
Sec 1 Naming alkanes of Bridged and spiro rings -Rings of carbon atoms (-CH2-groups) -Formula:CnH2n -Nonpolar,insoluble in water -Compact shape -Melting and boiling points similar to branched alkanes with same number of carbons
Sec 1 Naming alkanes of Bridged and spiro rings ▪Rings of carbon atoms (-CH2 - groups) ▪Formula: CnH2n ▪Nonpolar, insoluble in water ▪Compact shape ▪Melting and boiling points similar to branched alkanes with same number of carbons
Naming the following cycloalkanes. 1,1,2-trimethycyclohexane CH CH2CH 4-cyclopentyl-2,3-dimethylhexane trans-1-ethyl-2-methylcyclohexane 1,2-dicyclopropylethane ■Cycloalkane usually base compound。 Number carbons in ring if >1 substituent. First in alphabet gets lowest number. May be cycloalkyl attachment to chain
CH3 1 CH2CH3 2 trans-1-ethyl-2-methylcyclohexane 1,1,2-trimethycyclohexane 1,2-dicyclopropylethane 4-cyclopentyl-2,3-dimethylhexane ◼Cycloalkane usually base compound。 ◼Number carbons in ring if >1 substituent. ◼First in alphabet gets lowest number. ◼May be cycloalkyl attachment to chain. Naming the following cycloalkanes