结构与次黄嘌呤很相似的别嘌呤醇( allopurinol) 对黄嘌呤氧化酶有很强的抑制作用,可用来治疗痛风。 OH OH N C CH HC C HC Allopurinol Hypoxanthine (enol form Figure Allopurinol, an inhibitor of xanthine oxidase. Only a slight alteration(shaded) in the structure of the substrate hypoxanthine yields a medically effective enzyme inhibitor. Allopurinol is an example of a useful drug that was designed to be a competitive inhibitor
结构与次黄嘌呤很相似的别嘌呤醇(allopurinol) 对黄嘌呤氧化酶有很强的抑制作用,可用来治疗痛风
Gout H2N Guanine HN Xanthine Urate Inhibited by allopurinol OH HN Hypoxanthine
总结嘌呤的分解代谢
总结嘌呤的分解代谢
(五)嘧啶碱的分解代 RNA:Cyt、Ura N N Cytosine Uracil H H 时N-CH2CH2-c.+NH+(O 阝A anine
(五)嘧啶碱的分解代谢 RNA:Cyt、Ura
DNA: Th CH Thymine H HN一CH2CH2C+NH+ CHs B-Aminoisobutyric acid
DNA:Thy