Epoxides are Extremely Reactive lower Ea 25 HO: Kaua kcal OH ring strain higher Ea HO-R -:OR HORO-R reaction coordinate→
Epoxides are Extremely Reactive
Williamson Ether Synthesis Preparation of Unsymmetrical Ethers R-0:+Na R'-CHCxR-O-CH-R'+NaX alkoxide ion primary alkyl halide ether
Williamson Ether Synthesis Preparation of Unsymmetrical Ethers
Williamson Ether Synthesis:S2 R-0R'C多：→R一9-R'+:8: OH OCH,CH (1)Na (②)CH,CH2-OTs cyclohexanol ethoxycyclohexane (92%) H OCH (1)NaH (②)CH,-13 3,3-dimethyl-2-pentanol 2-methoxy-3,3-dimethylpentane (90%)
Williamson Ether Synthesis: SN2