From the Bark of the Pacific Yew Tree Taxol (Paclitaxel) Taxus brevifolia
From the Bark of the Pacific Yew Tree Taxol (Paclitaxel) O O NH O OH O O O OH O O OH O O O Taxus brevifolia
How Taxol Works A large number of microtubules are formed at the start of cell division,and as cell division comes to an end,these microtubules are normally broken down into tubulin -a protein responsible for the cell's structural stability. Taxol promotes tubulin polymerization then binds to the microtubules and inhibits their depolymerization back into tubulin. The cell can't divide into daughter cells and therefore the cancer can't spread
How Taxol Works • A large number of microtubules are formed at the start of cell division, and as cell division comes to an end, these microtubules are normally broken down into tubulin – a protein responsible for the cell’s structural stability. • Taxol promotes tubulin polymerization then binds to the microtubules and inhibits their depolymerization back into tubulin. • The cell can't divide into daughter cells and therefore the cancer can’t spread
May be More Effective than Taxol Epothilone B inhibits tubulin aggregation
May be More Effective than Taxol O OH O OH O O S N H Epothilone B inhibits tubulin aggregation
DNA Cross-linker 21 HO Azinomycin B Streptomyces sahachiroi
DNA Cross-linker CH3 CH3 O O O O O N H N O O H N HO AcO OH Azinomycin B Streptomyces sahachiroi 10 21
Prevents DNA from Unraveling OH OH OCH3 OH CH3 NH2 OH Doxorubicin (adriamycin) Binds to DNA and inhibits the enzyme topoisomerase II
Prevents DNA from Unraveling O O OH OH OCH3 O OH OH O NH2 OH CH3 Doxorubicin (adriamycin) Binds to DNA and inhibits the enzyme topoisomerase II