CH3 CHO+ CH2(COOH)2 C5H11N/Py COOH 60% OMe OMe CHO Ch2(COoH)2 CsH11N/Py Meo 87-98% Py,100C,2h CHO CH(COOH)2 CO2H 91-92% CHO O、COOH Ac, O/Et COOH HO OPh HO
C5 H11 N/Py COOH CHO OMe MeO C5 H11 N/Py OMe MeO COOH CH3 CHO + CH2 (COOH) 2 60% + CH2 (COOH) 2 87-98% O CHO + CH2 (COOH) 2 Py, 100 o C, 2h O CO2 H 91-92% CHO HO O COOH + Ac2 O/Et 3 N HO OPh COOH
Co2Et ArCHO+ CH2- 微量哌啶 CO,Et CO2H Ar ArCHO+CH2(CO2Et2-ERP EgE- Ar CO2Et co. 21 Et RCHo+cH2CoOE2厘R^0(副反应多) Co2Et O2N CHO COOH C5H1 N/Py O2N COmEt 100°C,6h 87% COoT C5H11N/PhCO2H COoT Hcho+CHCO0EzCe6回流去水 8991% COoT CH,CHO +CH(COOEt, CsHnN, COOEt CH2(CO2Et)2 EtO2 C CO2 CooT Eto 2C COEt
CH2 (CO2 Et) A 2 rCHO Ar CO2 Et CO2 Et CH2 (CO2 Et) RCHO 2 R CO2 Et CO2 Et ArCHO Ar CH CO2 Et 2 CO2 Et CO2 H + Py 微量哌啶 + Py 微量哌啶 (副反应多) + 微量哌啶 Py O2 N CHO COOEt COOH C5 H11 N/Py O2 N COOEt C5 H11 N/PhCO2 H C6 H6 COOEt COOEt C5 H11 N COOEt COOEt + 100 o C, 6h 87% PhCHO + CH2 (COOEt) 2 回流去水 89-91% CH3 CHO + CH2 (COOEt) 2 CH2 (CO2 Et) 2 CO2 Et E CO2 Et tO2 C EtO2 C