Risk Factors 3. Prolonged Use of estrogen a Prolonged menopausal estrogen replacement therapy without progestogen b. Prolonged use of the antiestrogen tamoxifen for breast cancer
Risk Factors 3. Prolonged Use of estrogen a. Prolonged menopausal estrogen replacement therapy without progestogen. b. Prolonged use of the antiestrogen tamoxifen for breast cancer
Risk Factors 4. Genetic factors and other factors a Endometrial and ovarian cancer are the simultaneously occurring with other genital malignancy reported incidence (14-38%) b. Family history of tumor is higher. (12 28%)
Risk Factors 4. Genetic factors and other factors a. Endometrial and ovarian cancer are the simultaneously occurring with other genital malignancy ,reported incidence (1.4~3.8%). b. Family history of tumor is higher.(12- 28%)
Classification Estrogen dependent and estrogen independent are two different pathogenetic types One with history of exposure to unopposed estrogen(either endogenous or exogenous) Other type with no source of estrogen stimulation of endometrium
Classification • Estrogen dependent and estrogen independent are two different pathogenetic types: -- One with history of exposure to unopposed estrogen (either endogenous or exogenous). -- Other type with no source of estrogen stimulation of endometrium
Five histological subtypes Endometrioid adenocarcinoma Mucinous carcinoma Serous adenocarcinoma Clear cell carcinoma Other rare subtypes
Five histological subtypes • Endometrioid adenocarcinoma • Mucinous carcinoma • Serous adenocarcinoma • Clear cell carcinoma • Other rare subtypes
Five histological subtypes Endometrioid adenocarcinoma · Account for about 80~90% ·We! differentiated Prognosis is better
Five histological subtypes --Endometrioid Adenocarcinoma • Account for about 80~90%. • Well differentiated. • Prognosis is better