The Third Chapter The Monogenic Disease
The Third Chapter The Monogenic Disease
Contents > Basic concepts and research methods of monogenic The basic genetics style of monogenic disease Influence factors of monogenic disease analysis Recurrence risk assessment of monogenic disease
Contents ➢ Basic concepts and research methods of monogenic ➢ The basic genetics style of monogenic disease ➢ Influence factors of monogenic disease analysis ➢ Recurrence risk assessment of monogenic disease
OMIM Statistics for Sept.13,2005 X Autosomal 15212 X-linked 906 Y-linked 56 Mitochondrial 62 16236 http://www.ncbi.nlm.nih.gov/Omim/mimstats.html
OMIM Statistics for Sept. 13, 2005 Autosomal 15212 X-linked 906 Y-linked 56 Mitochondrial 62 16236 http://www.ncbi.nlm.nih.gov/Omim/mimstats.html
Basic concepts of monogenic Alleles:alternate versions of the same gene Contributes to genetic variation GOOD. Homozygous:same allele from mom and dad ■Ex:AA,aa Heterozygous:different allele from mom and dad ■Ex:Aa,Bb Hemizygous:sex chromosomes are different Homomorphic (XX female),heteromorphic (XY male)
Basic concepts of monogenic ◆ Alleles: alternate versions of the same gene ◼ Contributes to genetic variation = GOOD. ◆ Homozygous: same allele from mom and dad ◼ Ex: AA, aa ◆ Heterozygous: different allele from mom and dad ◼ Ex: Aa, Bb ◆ Hemizygous: sex chromosomes are different ◼ Homomorphic (XX female), heteromorphic (XY male)
Allele for purple flowers Locus for Homologous flower-color pair of gene chromosomes Allele for white flowers CopyrightPearson Education,Incpublishing as Benjamin Cummings