MedicalGenetics Population Genetics
Population Genetics Medical Genetics
Emphasis Gene Frequency Genotypic Frequency *Law of Genetic Equilibrium Factors that Alter Genetic Equilibrium —Mutation,Selection Consanguineous Marriage Genetic Load
Emphasis ❖ Gene Frequency & Genotypic Frequency ❖ Law of Genetic Equilibrium ❖ Factors that Alter Genetic Equilibrium —— Mutation, Selection ❖ Consanguineous Marriage ❖ Genetic Load
Population genetics investigates genetic structure and genetic variation among individuals within groups. Mendelian population is a group of interbreeding individuals,who live in the same place and share a common set of genes (gene pool)
Population genetics investigates genetic structure and genetic variation among individuals within groups. Mendelian population is a group of interbreeding individuals, who live in the same place and share a common set of genes (gene pool)
Gene Frequency Genotypic Frequency Allelic frequency:a proportion or a percent of allele. Genotypic frequency:the number of individuals with one particular genotype divided by the total number of individuals in the population
Allelic frequency: a proportion or a percent of allele. Genotypic frequency: the number of individuals with one particular genotype divided by the total number of individuals in the population. Gene Frequency & Genotypic Frequency
Gene Frequency Genotypic Frequency M Genotype:MM 5;MN 7;NN 4 Allelic frequency of M:p三(2×5+7)/2×16)=0.5312 Allelic frequency of N:q=(2X4+7)/(2X16)=0.4688
Gene Frequency & Genotypic Frequency M N Genotype: MM 5; MN 7; NN 4 Allelic frequency of M：p ＝(2×5＋7)/(2×16)＝0.5312 Allelic frequency of N：q ＝(2×4＋7)/(2×16)＝0.4688