Many steps require an activated ribose sugar 0-POCH2O、H ATP AMP 0—POCH,O HH OH Ribose phos P-0-P-0 pyrophosphokinase HO OH HO OH O bose 5-phosphate 5-Phosphoribosyl-1-pyrophosphate (PRPP Activated carbon atom Ribose unit Space-filling model of 5-Phosphoribo syl-I-pyrophosphate(PRPP), the acti vated donor of the sugar unit in the biosynthesis of nucleotides
Many steps require an activated ribose sugar
The committed step in the do novo synthesis of purine nucleotides 0 O—PoCH2O、H Glutamine Glutamate-0-POCH20 NH HH 0K以+P 0-P-0-P-0 Amidophosphoribosyl transferase H HO OH 0-0 HO OH PRPP 5-Phosphoribosyl 1-amine
The committed step in the do novo synthesis of purine nucleotides
0-P-0-P一C a时 >plath 确 oLN "x、0 latdr IFCAR
w dIMP N eal 确 x abaci.)ALcAM) y'Formnl h sACAL E>“:
Purine biosynthesis (de novo) (A bunch of steps you dont need to know) 0 NC- CH (nosine Monophosphate) ATP GTP NH2 C C CH CH Feedback H,N H Inhibition
Purine Biosynthesis (de novo) ATP GTP (A bunch of steps you don’t need to know) N (Inosine Monophosphate) CH N C C N C N C O H N CH N C C N C N C O H2N H N C H N C C N C N C N H2 H Feedback Inhibition