HEMODYNAMIC DISORDERS yein(刘晔) Dept Pathology, SMC
Hemodynamic Disorders Ye Liu （刘 晔） Dept. Pathology, SMC
High ow Containing Pressure Pulmonary Arteries Pressure Heart, artery, Vein · Genera|crcu|aton Pulmonary circulation Lowest Highest Pressure Atum Pressure Functions Deliver oxygen and entec nutrients Carry away metabolic vastes A Healthy circulatory system ◆Noma/ blood volumn ◆ Homeostasis
Containing • Heart, artery, Vein • General circulation Pulmonary circulation Functions • Deliver oxygen and nutrients • Carry away metabolic wastes A Healthy circulatory system ♠ Normal blood volumn ♠ Homeostasis
Normal homeostasis vesse/Wa∥ integrit Edema intravascular pressure Hyperemia congestion osmolar · Thrombosis& Embolism normal hemostasis Infarction Hemorrhage Shock Three Major Causes of morbidity and mortality o Myocardial infarction ◆ Pulmonary embolism Cerebral vascular accident
Normal homeostasis vessel wall integrity intravascular pressure osmolarity normal hemostasis • Edema • Hyperemia & congestion • Thrombosis & Embolism • Infarction • Hemorrhage • Shock Three Major Causes of morbidity and mortality ♦ Myocardial infarction ♦ Pulmonary embolism ♦ Cerebral vascular accident
EDEMA(水肿) ncreased fluid in the interstitial tissue spaces To thoracito deft sand evant vell general local Pathogenesis 气 ncreased interstitial Hydrostatic pressure fluid pressure Vascular hydrostatic pressure Plasma colloid osmotic Plasma colloid pressure osmotic pressure Lymphatic drainage Arterial end CAPILLARY BED Venous end
EDEMA (水肿) • Increased fluid in the interstitial tissue spaces • General & local • Pathogenesis – Vascular hydrostatic pressure – Plasma colloid osmotic pressure – Lymphatic drainage
EDEMA Increased hydrostatic pressure C cardiac edema, etc Reduced plasma osmotic pressure (nephrotic, hepatic, malnutrient edema etc.) Lymphatic obstruction (filariasis infection-elephantiasis, breast surgery, etc) Sodium and water retention(ARf etc) elephantiasis Minimal change disease Pitting edema
EDEMA • Increased hydrostatic pressure ( cardiac edema, etc.) • Reduced plasma osmotic pressure (nephrotic, hepatic, malnutrient edema, etc. ) • Lymphatic obstruction (filariasis infection — elephantiasis，breast surgery, etc ) • Sodium and water retention (ARF, etc) elephantiasis Minimal Change Disease Pitting edema