溶血性贫血 Hemolytic Anemia 华山医院血液科 陈勤奋
溶血性贫血 Hemolytic Anemia 华山医院血液科 陈勤奋
HEMOLYTIC ANEMIA (reduced RBC life span) Anemia of increased destruction CRNormochrom1c. normochromic anemia a& Shortened rBC survival cRReticulocytosis--Response to increased rbc destruction cRIncreased indirect bilirubin iNCreased LDh
HEMOLYTIC ANEMIA (reduced RBC life span) ❖Anemia of increased destruction Normochromic, normochromic anemia Shortened RBC survival Reticulocytosis--Response to increased RBC destruction Increased indirect bilirubin Increased LDH
Mechanisms and Causes 令Ⅰ NTRACORPUSCULAR HEMOLYSIS mEMbrane Abnormalities METabolic abnormalities heMoglobinopathies EXTRACORPUSCULAR HEMOLYSIS nONimmune ORImune
Mechanisms and Causes ❖INTRACORPUSCULAR HEMOLYSIS Membrane Abnormalities Metabolic Abnormalities Hemoglobinopathies ❖EXTRACORPUSCULAR HEMOLYSIS Nonimmune Immune
Membrane defects Microskeletal defects cOHereditary spherocytosis o Increased sensitivity to complement paRoxysmal nocturnal hemoglobinuria
Membrane Defects ❖Microskeletal defects Hereditary spherocytosis ❖Increased sensitivity to complement Paroxysmal nocturnal hemoglobinuria
Enzymopathies % Glucose 6-Phosphate Dehydrogenase Deficiency o Pyruvate Kinase Deficiency
Enzymopathies ❖Glucose 6-Phosphate Dehydrogenase Deficiency ❖Pyruvate Kinase Deficiency