上降文通大学 SHANGHAI JLAO TONG UNIVERSITY 临床医学与材料 (二) 漏 孙康教授 材料科学与工程学院 BWnn 2018-10-13 WA SHANG 1日g6
临床医学与材料 （二） 孙康 教授 材料科学与工程学院 2018-10-13
上游充通大学 SHANGHAI JIAO TONG UNIVERSITY 创伤愈合是指机体遭受外力作 用，器官组织出现离断或缺损 后的愈复过程，包括了各种组 织的再生和肉芽组织增生、瘢 痕形成的复杂组合，表现出各 种修复过程的协同作用。 ● 损伤的程度及组织的再生能力 血液泵 透析液血液 决定修复的方式、愈合的时间 及瘢痕的大小。损伤组织的再 生与修复是机体在生物进化过 半透膜 程中获得的，因此机体的全身 和局部因素，均可影响组织的 液 再生修复。影响再生修复的因 用过的 素包括全身因素及局部因素两 透析液 方面。 血液透析图
创伤愈合是指机体遭受外力作 用，器官组织出现离断或缺损 后的愈复过程，包括了各种组 织的再生和肉芽组织增生、瘢 痕形成的复杂组合，表现出各 种修复过程的协同作用。 损伤的程度及组织的再生能力 决定修复的方式、愈合的时间 及瘢痕的大小。损伤组织的再 生与修复是机体在生物进化过 程中获得的，因此机体的全身 和局部因素，均可影响组织的 再生修复。影响再生修复的因 素包括全身因素及局部因素两 方面
上游充通大学 SHANGHAI JIAO TONG UNIVERSITY Tissue Engineering Tissue damage or organ failure resulting from injury or disease is a major health care problem,and the transplantation of tissues or organs is severely limited.Since 1988,Tissue engineering is a new but rapidly growing field that uses implanted cells,scaffolds,and biologically active molecules to replace or repair injured or diseased tissues and organs. Nervous tissue:Internal communication Brain,spinal cord,and nerves Cell source Novel chemistries Engineering cells iPSCs 器心 Engineering Muscle tissue:Contracts to cause movement Muscles attached to bones (skeletal) Adult stem Muscles of heart(cardiac) Muscles of walls of hollow organs(smooth) cells Growth factors aterials Epithelial tissue:Forms boundaries between different environments,protects,secretes,absorbs,filters Lining of Gl tract organs and other hollow organs Skin surface (epidermis) Genetic tools Progress in tissue engineering Biomechanics CRISPR-Cas9 Connective tissue:Supports,protects,binds other tissues together Bones Decellularized Tendons Fat and other soft padding tissue Self assembly 3D printing organs 日日日且 Engineering tissue architecture Journal of Biomedical Materials Research banner,53(6),2000
3 Tissue Engineering Tissue damage or organ failure resulting from injury or disease is a major health care problem, and the transplantation of tissues or organs is severely limited. Since 1988, Tissue engineering is a new but rapidly growing field that uses implanted cells, scaffolds, and biologically active molecules to replace or repair injured or diseased tissues and organs. Journal of Biomedical Materials Research banner, 53(6),2000
With the development of research,tissue engineering has progressed rapidly in kinds of tissues,such as skin,blood vessels,liver,bone,nerve, e.g. growth cone SCAFFOLD 3 (Peptide WITH growth factors BIOMIMETIC Blood vessel SEQUENCES focal adhesion Factor A BFactor B SCAFFOLD RELEASING GEs biomaterial-based NGC Factor c with intraluminal filaments Platelet-rich Schwann cell regenerating axon PLATELETS ● GENE TRANSFER 00 intraluminal filament 90 Stem Cell Niche (Bone Marrow. Surrounding Tissues...) ACTIVELY PRODUCING CELLS (EPCs) B Biomaterials 35,2014,6143-6156;Neural Regeneration,2015,73-99;Biomedical Engineering,40(5),2012,363-408
With the development of research, tissue engineering has progressed rapidly in kinds of tissues, such as skin, blood vessels, liver, bone, nerve, e.g. Biomaterials 35,2014, 6143-6156;Neural Regeneration, 2015, 73-99;Biomedical Engineering, 40(5), 2012, 363–408
LIMB HAND N individual motor GRIPS for each digit Koy Precision Fully articulated joints Power uscles to make Schematic of pacemaker system