Ischemia-Reperfusion Injury and free radicals Jianzhong Sheng Md PhD
Ischemia-Reperfusion Injury and Free Radicals Jianzhong Sheng MD PhD
History n 1955, Sewell et al reported that ventricular fibrillation occurred in dogs When sudden return of blood flow to the coronary artery that was ligated
• In 1955，Sewell et al., reported that ventricular fibrillation occurred in dogs when sudden return of blood flow to the coronary artery that was ligated History
Myocardial reperfusion injury was first postulated in 1960 by Jennings et al. in their description of the histologic features of reperfused ischemic canine myocardium The injury of ischemic cardiac muscles was more severe after reperfusion than before
• Myocardial reperfusion injury was first postulated in 1960 by Jennings et al. in their description of the histologic features of reperfused ischemic canine myocardium. The injury of ischemic cardiac muscles was more severe after reperfusion than before
1967, Bulkley and Hutchins found that reflow of blood induced necrosis of cardiac myocytes after coronary artery bypass graft surgery. 1981, Greenberg confirmed that reperfusion induced severe damage of the intestinal mucosal cells of cat after 3 hours of ischemia
• 1967，Bulkley and Hutchins found that reflow of blood induced necrosis of cardiac myocytes after coronary artery bypass graft surgery. • 1981, Greenberg confirmed that reperfusion induced severe damage of the intestinal mucosal cells of cat after 3 hours of ischemia
Clinice Shock, DIC microcirculation reperfusion Coronary reperfusion, artery bypass graft Restoration of blood supply in reimplantation of limb, transplantation of organs
Clinic: • Shock, DIC microcirculation reperfusion • Coronary reperfusion、artery bypass graft • Restoration of blood supply in reimplantation of limb, transplantation of organs