Human Immunodeficiency Virus and Acquired Immunodeficiency Syndromes Dongli pan Department of Medical Microbiology and Parasitology Zhejiang University School of Medicine pandongli@zju. edu.cl
Human Immunodeficiency Virus and Acquired Immunodeficiency Syndromes Dongli Pan Department of Medical Microbiology and Parasitology Zhejiang University School of Medicine pandongli@zju.edu.cn
DNA Viruses RNA Viruses Group I Group‖l Group Ill Group Group V Group VI Group VI DNA(+/-) DNA (+ RNA(+/-) RNA(+) RNA(-) RNA(+) DNA(+/-) ranscription DCOOOOOO RNA(-) DNA(+/- Reverse transcription RNA prot Baltimore classification Fields Virology 6th edition
Fields Virology, 6th edition DNA viruses RNA viruses Baltimore classification
People estimated to be living with HIV(2014 WORLD AIDS DAY Eastern Euro North America and Western and Central Europe&Central Asia 2.4 million [1.5 million- 3.5 milionI (1.3 million-1.8 million) Middle East North Africa bean 240000 000 1500032000 Asia and the Pacific n2100004000 5.0 million Sub- Saharan Africa 种5 millIon=56moh Latin America 25.8 millior 1.7 million 240 [4 million-2.0 million Total: 36.9 million [34.3 million.4 million
People estimated to be living with HIV (2014)
How was hi discovered 1980-1981, 5 young men, all active homosexuals, were treated for Pneumocystis carini pneumonia(PCP)in LA, CA. The symptoms suggest the possibility of cellular-immune dysfunction Clusters of PCP and Kaposi's sarcoma observed in other hospitals 1982 disease started to be called aids Found transmitted at birth and heterosexually Virus was first isolated in 1983 from the lymph node of a patient with lymphadenopathy in Paris 1984 Electron microscopy and sequence anal ysis revealed hiv to be a lentivirus, known group of retroviruses
How was HIV discovered • In 1980-1981, 5 young men, all active homosexuals, were treated for Pneumocystis carinii pneumonia (PCP) in LA, CA. The symptoms suggest the possibility of cellular-immune dysfunction. • Clusters of PCP and Kaposi’s sarcoma observed in other hospitals. • 1982 disease started to be called AIDS. • Found transmitted at birth and heterosexually. • Virus was first isolated in 1983 from the lymph node of a patient with lymphadenopathy in Paris. • 1984 Electron microscopy and sequence analysis revealed HIV to be a lentivirus, known group of retroviruses
Where is hiv from Hr-2 Vsmr Syes's monkey Sooty SiVgsnSiVmus/SIMon SIVsyk) s/vamn Ptt of central africa StOol SiMon Mantled guereza Mona monkey HIV-1 M&N SIvcpz SIVe SIRcam chimpanzee s/Vho(s/vmnd SIVcpz SIVer Vervet monkey Red-capped HiV-1 P60 /estern goia LHoest's monkey Mandrill Cold Spring Harb Perspect Med 2011: 1:0006841
Where is HIV from