Neonatal Jaundice and Hemolysis bazhou@shmu.edu.cn
Neonatal Jaundice and Hemolysis bhzhou@shmu.edu.cn
Jaundice黄疸 Bilirubin胆红素 Hyperbilirubinemia高胆红素血症
Jaundice 黄疸 Bilirubin 胆红素 Hyperbilirubinemia 高胆红素血症
Jaundice is a common neonatal problem. sixty-five percent of newborns develop clinical jaundice with a bilirubin level above 5 mg/d during the first week of life
Jaundice is a common neonatal problem. Sixty-five percent of newborns develop clinical jaundice with a bilirubin level above 5 mg/dl during the first week of life
Metabolism of bilirubin production↑: breakdown 1 g hemoglobin 34 mg bilirubin Adult 3.8 mg /kg.d Neonatal 8.5mg /kg.d cleaning v: Protein Y and Z l(in liver cell UDPGⅣ↓( glucuronyl transferase-葡萄糖醛酸转移酶) the enterohepatic circulation of bilirubin
Metabolism of bilirubin production ： 1 g hemoglobin 34 mg bilirubin Adult 3.8 mg / kg.d， Neonatal 8.5mg / kg.d， cleaning : Protein Y and Z (in liver cell ) UDPGT（glucuronyl transferase - 葡萄糖醛酸转移酶） the enterohepatic circulation of bilirubin breakdown
Maisels in 1981 Clincial jaundice appears in 24 hour after born Total bilirubin level rises >5 mg /dl per day Peak bilirubin level >12.9mg /dl (term baby)or >15 mg /dl premature baby Conjugated bilirubin level >1.5--2.0 mg/dl a Clincial jaundice is not resolved by 1 week in term infant or 2 week in preterm infant
Maisels in 1981 ◼ Clincial jaundice appears in 24 hour after born ◼ Total bilirubin level rises >5 mg / dl per day ◼ Peak bilirubin level > 12.9mg / dl (term baby) or >15 mg / dl ( premature baby) ◼ Conjugated bilirubin level >1.5--2.0 mg / dl ◼ Clincial jaundice is not resolved by 1 week in term infant or 2 week in preterm infant