ALZHEIMER DISEASE Commonest cause of dementias majority) Sporadic, 5-10% familial CORTICAL (grey matter) ATROPHY NEURITIC PLAQUESX lextraneuronal NEUROFIBRILLARY TANGLES (intraneuronal) AMYLOID!!!(Le,,"BETA amyloid)
ALZHEIMER DISEASE • Commonest cause of dementias (majority) • Sporadic, 5-10% familial • CORTICAL (grey matter) ATROPHY • NEURITIC PLAQUES* (extraneuronal) • NEUROFIBRILLARY TANGLES (intraneuronal) • AMYLOID!!! (i.e., “BETA” amyloid)
