159 CHAPTER SEVE Preventing risks and Taking action More emphasis on preventing the causes of important diseases is the key to improving world health. Tackling major risks effectively could lead to up to ten years more of healthy life expectancy globally. Although the world faces some common, large and certain risks to health, effective and affordable interventions are available. Very substantial gains can be made for relatively modest expenditures, but bold government policies will be required. They should prioritize the most important risks and shift the main focus to include preventive measures that can be applied to the whole population. For example, governments can decide to aim for increased taxes on tobacco; legislation to reduce the proportion of salt and other unhealthy components in foods; stricter environmental controls and ambitious energy policies; and stronger health promotion and health safety campaigns. Reducing major risks will in turn reduce inequities in society, and promote both healthy life and sustainable
Preventing Risks and Taking Action 159 reventing isks and aking ction 159 CHAPTER SEVEN More emphasis on preventing the causes of important diseases is the key to improving world health. Tackling major risks effectively could lead to up to ten years more of healthy life expectancy globally. Although the world faces some common, large and certain risks to health, effective and affordable interventions are available. Very substantial gains can be made for relatively modest expenditures, but bold government policies will be required. They should prioritize the most important risks and shift the main focus to include preventive measures that can be applied to the whole population. For example, governments can decide to aim for increased taxes on tobacco; legislation to reduce the proportion of salt and other unhealthy components in foods; stricter environmental controls and ambitious energy policies; and stronger health promotion and health safety campaigns. Reducing major risks will in turn reduce inequities in society, and promote both healthy life and sustainable development.
161 PREVENTING RISKS AND TAKING ACTION FOCUSING ON PREVENTION MEANS FOCUSING ON RISKS n order to protect and improve health around the world, much more emphasis is needed preventing the actual causes of important diseases- the underlying risks to health as well as treating the established diseases themselves. Prevention can best be achieved rough concerted efforts to identify and reduce common, major risks and by taking ad vantage of the prevention opportunities they present his report shows that about 47% of global mortality is attributable to the leading 20 risk factors that have been assessed in earlier chapters, and that more than one third of that burden is attributable to just 10 of those factors. Tackling these risks effectively could lead to almost a decade more of healthy life expectancy globally. The potential improvements in global health are much greater than generally realized- extra years of healthy life expect ancy could be gained for populations in all countries within the next decade The greatest gains would be in some of the poorest nations- with perhaps ten more healthy life years achievable. The potential benefits extend across all countries and all levels of socioeconomic development. Even in the most developed countries of North America and Europe, another five or so years of healthy life expectancy for the population is within Looking towards the potential global burden of disease in the next two decades, Chap- ter 4 showed that reducing risk by 25% will result in large amounts of that burden being avoided. Translated into human terms, this offers the prospect of millions of premature deaths being averted, and of many more millions of people being spared years of disease, disability and ill-health. It might mean, for example, that in the year 2010 more than a million deaths from HIVAIDS and the loss of 40 million healthy life years related to unsafe sex would be averted, as would more than a million deaths and over 35 million lost healthy life years from cardiovascular diseases related to blood pressure and cholesterol However, Chapter 4 also gave a measure of the cost of inaction. It predicted that by the rear 2020 there will be nne n nillion deaths caused by tobacco, compared to almost five million a year now; five million deaths attributable to overweight and obesity, compare three million now; and that the number of healthy life years lost by underweight children will be 60 million, which although less than half the 130 million now, is still unacceptably
Preventing Risks and Taking Action 161 7 PREVENTING RISKS AND TAKING ACTION FOCUSING ON PREVENTION MEANS FOCUSING ON RISKS n order to protect and improve health around the world, much more emphasis is needed on preventing the actual causes of important diseases – the underlying risks to health – as well as treating the established diseases themselves. Prevention can best be achieved through concerted efforts to identify and reduce common, major risks and by taking advantage of the prevention opportunities they present. This report shows that about 47% of global mortality is attributable to the leading 20 risk factors that have been assessed in earlier chapters, and that more than one third of that burden is attributable to just 10 of those factors. Tackling these risks effectively could lead to almost a decade more of healthy life expectancy globally. The potential improvements in global health are much greater than generally realized – extra years of healthy life expectancy could be gained for populations in all countries within the next decade. The greatest gains would be in some of the poorest nations – with perhaps ten more healthy life years achievable. The potential benefits extend across all countries and all levels of socioeconomic development. Even in the most developed countries of North America and Europe, another five or so years of healthy life expectancy for the population is within reach. Looking towards the potential global burden of disease in the next two decades, Chapter 4 showed that reducing risk by 25% will result in large amounts of that burden being avoided. Translated into human terms, this offers the prospect of millions of premature deaths being averted, and of many more millions of people being spared years of disease, disability and ill-health. It might mean, for example, that in the year 2010 more than a million deaths from HIV/AIDS and the loss of 40 million healthy life years related to unsafe sex would be averted, as would more than a million deaths and over 35 million lost healthy life years from cardiovascular diseases related to blood pressure and cholesterol. However, Chapter 4 also gave a measure of the cost of inaction. It predicted that by the year 2020 there will be nine million deaths caused by tobacco, compared to almost five million a year now; five million deaths attributable to overweight and obesity, compared to three million now; and that the number of healthy life years lost by underweight children will be 60 million, which although less than half the 130 million now, is still unacceptably high
162 The World Health Report 2002 This report represents one of the largest research projects ever coordinated by the World Health Organization. It has quantified many of the important global risks and assessed the cost-effectiveness of measures to reduce them. The ultimate goal is to support gover ments in all countries to lower the impact of these risk The conclusions have already been described as a wake-up call to health leaders around the world. They are also the basis for building a healthier future for entire populations THE WORLD FACES SOME COMMON LARGE AND CERTAIN RISKS TO HEALTH Leading 10 selected risk factors as percentage causes of There are countless risks to health, but even among the selected disease burden measured in dalys major risks in this report, relatively few are responsible for large amounts of the global disease burden. Almost all of them are more Developing countries common among the world's poor than the better-off. Until now, their High mortality countries true impact has been underestimated, particularly in developing coun underweight tnes Unsafe sex 102% Unsafe water, sanitation and hygiene 5 59 The picture that has emerged from this research gives an intrigu Indoor smoke from solid fuels 3.6n.ing a alarming-insight into current and important causes of Zinc deficiency 3.296 diseases and death and the factors underlying them. Human behav- 3.19 jour and societies are changing around the world and global changes Vitamin A deficiency 3.0% are having a large impact on peoples health Blood pressure 2.5% The table, left, shows the top 10 selected risk factors as causes of Tobacco 2.0% disease burden in high and low mortality developing countries and holesterol 1.9% in developed countries. While this table shows the burden attribut- Low mortality cour able to the selected factors at a global level, it does not show the high 6.29 risks faced by certain sections of the population( for example, the Blood pressure 5.09 many people whose occupations place them at high risk of life-threat 4.0% ening injury or chronic disease), or the burden resulting from major Underweight 3.1% diseases(such as malaria, tuberculosis and HiViaidS which in total Overweight 2.7% cause more than 10% of global disease burden). Also, the combined holesterol 2.1% effects of the risk factors in this table will be less than the sum of their Low fruit and vegetable intake Indoor smoke from solid fuels 1.9% Separate effects At least 30%%of all disease burden occurring in high mortal- 1.8%0 ity developing countries, such as those in sub-Saharan Africa Unsafe water, sanitation and hygiene 1.8% and South-East Asia, is due to just five risk factors: underweight Developed countries unsafe sex, micronutrient deficiencies, unsafe water, and in Tobacco door smoke Risks associated with food insecurity, hunger and 122% Blood pressure 109% malnutrition still dominate the health of the world,'s poorest nations. Most of the childhood deaths in developing countries Cholesterol 756% each year are associated with malnutrition. In addition, the 74% onsequences of unsafe sex are fuelling the HIVIAIDS epide ics in africa and asia Physical inactivity 33%. In low mortality developing countries, such as the Peoples llicit drugs Republic of China and most countries in Central and South Unsafe sex 0.8% America, the top five risk factors cause at least one sixth of on deficiency their total disease burden. These populations face a double burden of risks. Indeed, the analysis on which this report
162 The World Health Report 2002 This report represents one of the largest research projects ever coordinated by the World Health Organization. It has quantified many of the important global risks and assessed the cost-effectiveness of measures to reduce them. The ultimate goal is to support governments in all countries to lower the impact of these risks. The conclusions have already been described as a wake-up call to health leaders around the world. They are also the basis for building a healthier future for entire populations across the world. THE WORLD FACES SOME COMMON, LARGE AND CERTAIN RISKS TO HEALTH There are countless risks to health, but even among the selected major risks in this report, relatively few are responsible for large amounts of the global disease burden. Almost all of them are more common among the world’s poor than the better-off. Until now, their true impact has been underestimated, particularly in developing countries. The picture that has emerged from this research gives an intriguing – and alarming – insight into current and important causes of diseases and death and the factors underlying them. Human behaviour and societies are changing around the world and global changes are having a large impact on people’s health. The table, left, shows the top 10 selected risk factors as causes of disease burden in high and low mortality developing countries and in developed countries. While this table shows the burden attributable to the selected factors at a global level, it does not show the high risks faced by certain sections of the population (for example, the many people whose occupations place them at high risk of life-threatening injury or chronic disease), or the burden resulting from major diseases (such as malaria, tuberculosis and HIV/AIDS which in total cause more than 10% of global disease burden). Also, the combined effects of the risk factors in this table will be less than the sum of their separate effects. • At least 30%% of all disease burden occurring in high mortality developing countries, such as those in sub-Saharan Africa and South-East Asia, is due to just five risk factors: underweight, unsafe sex, micronutrient deficiencies, unsafe water, and indoor smoke. Risks associated with food insecurity, hunger and malnutrition still dominate the health of the world’s poorest nations. Most of the childhood deaths in developing countries each year are associated with malnutrition. In addition, the consequences of unsafe sex are fuelling the HIV/AIDS epidemics in Africa and Asia. • In low mortality developing countries, such as the People’s Republic of China and most countries in Central and South America, the top five risk factors cause at least one sixth of their total disease burden. These populations face a double burden of risks. Indeed, the analysis on which this report is Leading 10 selected risk factors as percentage causes of disease burden measured in DALYs Developing countries High mortality countries Underweight 14.9% Unsafe sex 10.2% Unsafe water, sanitation and hygiene 5.5% Indoor smoke from solid fuels 3.6% Zinc deficiency 3.2% Iron deficiency 3.1% Vitamin A deficiency 3.0% Blood pressure 2.5% Tobacco 2.0% Cholesterol 1.9% Low mortality countries Alcohol 6.2% Blood pressure 5.0% Tobacco 4.0% Underweight 3.1% Overweight 2.7% Cholesterol 2.1% Low fruit and vegetable intake 1.9% Indoor smoke from solid fuels 1.9% Iron deficiency 1.8% Unsafe water, sanitation and hygiene 1.8% Developed countries Tobacco 12.2% Blood pressure 10.9% Alcohol 9.2% Cholesterol 7.6% Overweight 7.4% Low fruit and vegetable intake 3.9% Physical inactivity 3.3% Illicit drugs 1.8% Unsafe sex 0.8% Iron deficiency 0.7%
Preventing Risks and Taking Action based shows how these countries already face many of the same risks as industrial ized countries-tobacco and high blood pressure, for example- while also having to contend with major remaining problems of undernutrition and communicable diseases At the same time in the developed countries of North America, Europe and the Asian Pacific, at least one-third of all disease burden is attributable to these five risk factors. bacco, alcohol, blood pressure, cholesterol and obesity. The tobacco epidemic alone kills about 2.4 million people every year in industrialized countries. In addition, suboptimal levels of blood pressure and cholesterol each cause millions of deaths annually, and increasing levels of overweight are leading to epidemics of obesity and diabetes The world is living dangerously either because it has little choice, or because it is making the wrong choices. Today there are more than six billion people coexisting on this fragile planet. On one side are the many millions who are dangerously short of the food, water and security they need to live. Developing countries still face a high and highly con centrated burden from poverty, undernutrition, unsafe sex, unsafe water, poor sanitation unhealthy consumption, particularly of tobacco and alcohol. The risks from blood pressure and cholesterol, strongly linked to heart attacks and strokes, are also closely related to excessive consumption of fatty, sugary and salty foods. They become even more dangerous when combined with the deadly forces of tobacco and excessive alcohol consumption Obesity, a result of unhealthy consumption coupled with lack of physical activity, is itself a All of these risk factors-blood pressure, cholesterol, tobacco, alcohol and obesity-and the diseases linked to them are well known to wealthy societies. The real drama is that they now also increasingly dominate in low mortality developing countries where they create a double burden on top of the infectious diseases that always have afflicted poorer countries They are even becoming more prevalent in high mortality developing countries EFFECTIVE AND AFFORDABLE PREVENTIVE INTERVENTIONS ARE AVAILABLE Every country has major risks to health that are known, definite and times largely unchecked; cost-effective interventions exist but are underutilized Very substantial health gains can be made for relatively modest expenditures. Chapter 4 examined in detail the cost-effectiveness of many interventions. Some of the most impor- tant findings are briefly described belor A strategy to protect the child's environment is cost-effective in all settings, with very cost-effective components including some form of micronutrient supplementation, such as vitamin A, iron, and zinc; disinfection of water at point of use to reduce the incidence of diarrhoeal diseases; and treatment of diarrhoea and pneumonia Improved water supply based on disinfection at point of use is cost-effective in re- gions of high child mortality. While acknowledging that regulated piped water sup plies will be the long-term aim of most countries, a policy shift towards household water management appears to be the most attractive short-term water-related health intervention in developing countries reventive interventions to reduce the incidence of HIV infections, including meas- ures to encourage safer injection practices, are very cost-effective. The use of some
Preventing Risks and Taking Action 163 based shows how these countries already face many of the same risks as industrialized countries – tobacco and high blood pressure, for example – while also having to contend with major remaining problems of undernutrition and communicable diseases. • At the same time in the developed countries of North America, Europe and the Asian Pacific, at least one-third of all disease burden is attributable to these five risk factors: tobacco, alcohol, blood pressure, cholesterol and obesity. The tobacco epidemic alone kills about 2.4 million people every year in industrialized countries. In addition, suboptimal levels of blood pressure and cholesterol each cause millions of deaths annually, and increasing levels of overweight are leading to epidemics of obesity and diabetes. The world is living dangerously – either because it has little choice, or because it is making the wrong choices. Today there are more than six billion people coexisting on this fragile planet. On one side are the many millions who are dangerously short of the food, water and security they need to live. Developing countries still face a high and highly concentrated burden from poverty, undernutrition, unsafe sex, unsafe water, poor sanitation and hygiene, iron deficiency and indoor smoke from solid fuels. On the other side lies unhealthy consumption, particularly of tobacco and alcohol. The risks from blood pressure and cholesterol, strongly linked to heart attacks and strokes, are also closely related to excessive consumption of fatty, sugary and salty foods. They become even more dangerous when combined with the deadly forces of tobacco and excessive alcohol consumption. Obesity, a result of unhealthy consumption coupled with lack of physical activity, is itself a serious health risk. All of these risk factors – blood pressure, cholesterol, tobacco, alcohol and obesity – and the diseases linked to them are well known to wealthy societies. The real drama is that they now also increasingly dominate in low mortality developing countries where they create a double burden on top of the infectious diseases that always have afflicted poorer countries. They are even becoming more prevalent in high mortality developing countries. EFFECTIVE AND AFFORDABLE PREVENTIVE INTERVENTIONS ARE AVAILABLE Every country has major risks to health that are known, definite and increasing, sometimes largely unchecked; cost-effective interventions exist but are underutilized. Very substantial health gains can be made for relatively modest expenditures. Chapter 4 examined in detail the cost-effectiveness of many interventions. Some of the most important findings are briefly described below. • A strategy to protect the child’s environment is cost-effective in all settings, with very cost-effective components including some form of micronutrient supplementation, such as vitamin A, iron, and zinc; disinfection of water at point of use to reduce the incidence of diarrhoeal diseases; and treatment of diarrhoea and pneumonia. • Improved water supply based on disinfection at point of use is cost-effective in regions of high child mortality. While acknowledging that regulated piped water supplies will be the long-term aim of most countries, a policy shift towards household water management appears to be the most attractive short-term water-related health intervention in developing countries. • Preventive interventions to reduce the incidence of HIV infections, including measures to encourage safer injection practices, are very cost-effective. The use of some
The World Health Report 2002 types of antiretroviral therapy in conjunction with preventive activities is cost-effec tive in most settings At least one type of intervention to reduce the risks associated with cardiovascular disease is cost-effective in all settings. Population-wide salt and cholesterol lowering strategies are always very cost-effective singly and combined. The most attractive combined strategy to reduce the risks associated with cardiovascular disease appears to be the combination of salt reduction at a population level through legislation or voluntary agreements, health education through the mass media focusing on blood pressure, cholesterol and overweight; plus the implementation of an individual risk Tobacco, of course, is a major risk for cardiovascular Some of the affordable solutions described in this report are disease. In terms of interventions, the greatest tobacco- closely related to two priority actions that WHO has outlined for related improvements in population health would be a the coming years: combination of tobacco taxation, comprehensive bans promoting healthy environments for children on advertising, and information dissemination activities, reinvigorating WHOs workon diet, food safety and human nutrition, all of which would be affordable and cost-effective in linking basic research with efforts to tackle specific nutrient most parts ot the world. Adding restrictions of smoking deficiencies in populations and the promotion of good health in public places increases the costs, but also gains even through optimal diets- particularly in countries undergoing rapid greater improvements in population health and is still nutritional transition rery cost-effective in industrialized countries NARROWING THE GAP BETWEEN POTENTIAL AND ACTUAL BENEFIT A KEY RESEARCH PRIORITY Despite the availability of cost-effective interventions to reduce risks, this report says ere is a large potential benefit that is not realizable with current strategies and technolo- gies Unacceptably large gaps remain in understanding the effects of exposures on populations at different stages of development. Similar uncertainties apply to how healt ystems might be better adapted to achieve substantial overall health gains through more affordable preparations and delivery methods. More fundamental research is needed in order to transfer effectively the scientific knowledge on hazards that will help change hu man behaviour and lower individual risks. If policy-makers are to be more effectively en gaged in applying measures that have proven benefits in risk reduction, the political context of knowledge transfer and risk management needs to be better understood and utilized. A key research priority is the development of new interventions, particularly for leading dis eases.Together with more efficient primary prevention, these interventions can be expected to reduce substantially the risk burden in all populations POPULATION-WIDE PREVENTION STRATEGIES KEY TO RISK REDUCTION It makes little sense to expect individuals to behave differently from their peers; it is more appropriate to seek a general change in behavioural norms and in the circumstances which facili tate theiradoption "(Rose, 1982) The great potential of prevention strategies that aim to achieve moderate, but popula tion-wide, reductions in risks is yet to be fully recognized. Only a fraction of the benefits
164 The World Health Report 2002 types of antiretroviral therapy in conjunction with preventive activities is cost-effective in most settings. • At least one type of intervention to reduce the risks associated with cardiovascular disease is cost-effective in all settings. Population-wide salt and cholesterol lowering strategies are always very cost-effective singly and combined. The most attractive combined strategy to reduce the risks associated with cardiovascular disease appears to be the combination of salt reduction at a population level through legislation or voluntary agreements, health education through the mass media focusing on blood pressure, cholesterol and overweight; plus the implementation of an individual risk reduction approach. • Tobacco, of course, is a major risk for cardiovascular disease. In terms of interventions, the greatest tobaccorelated improvements in population health would be a combination of tobacco taxation, comprehensive bans on advertising, and information dissemination activities, all of which would be affordable and cost-effective in most parts of the world. Adding restrictions of smoking in public places increases the costs, but also gains even greater improvements in population health and is still very cost-effective in industrialized countries. NARROWING THE GAP BETWEEN POTENTIAL AND ACTUAL BENEFIT: A KEY RESEARCH PRIORITY Despite the availability of cost-effective interventions to reduce risks, this report says there is a large potential benefit that is not realizable with current strategies and technologies. Unacceptably large gaps remain in understanding the effects of exposures on populations at different stages of development. Similar uncertainties apply to how health systems might be better adapted to achieve substantial overall health gains through more affordable preparations and delivery methods. More fundamental research is needed in order to transfer effectively the scientific knowledge on hazards that will help change human behaviour and lower individual risks. If policy-makers are to be more effectively engaged in applying measures that have proven benefits in risk reduction, the political context of knowledge transfer and risk management needs to be better understood and utilized. A key research priority is the development of new interventions, particularly for leading diseases. Together with more efficient primary prevention, these interventions can be expected to reduce substantially the risk burden in all populations. POPULATION-WIDE PREVENTION STRATEGIES: KEY TO RISK REDUCTION “It makes little sense to expect individuals to behave differently from their peers; it is more appropriate to seek a general change in behavioural norms and in the circumstances which facilitate their adoption.” (Rose, 1982) The great potential of prevention strategies that aim to achieve moderate, but population-wide, reductions in risks is yet to be fully recognized. Only a fraction of the benefits Some of the affordable solutions described in this report are closely related to two priority actions that WHO has outlined for the coming years: • promoting healthy environments for children; • reinvigorating WHO’s work on diet, food safety and human nutrition, linking basic research with efforts to tackle specific nutrient deficiencies in populations and the promotion of good health through optimal diets – particularly in countries undergoing rapid nutritional transition