肿瘤蛋白质标志物研究的新技术新方法 陆豪杰 复旦大学化学系&生物医学研究院
肿瘤蛋白质标志物研究的新技术新方法 陆豪杰 复旦大学化学系 &生物医学研究院
2002 John B Fenn, Koichi Tanaka, John B Fenn and Koichi Tanaka"for their development of soft Kurt Wuthrich desorption ionisation methods for mass spectrometric analyses of biological macromolecules"and Kurt Wuthrich"for his development of nuclear magnetic resonance spectroscopy for determining the three-dimensional structure of biological macromolecules in solution 2003 Peter Agre, Roderick to Peter Agre"for the discovery of water channels"and with one Mackinnon half to roderick mackinnon "for structural and mechanistic studies of ion channels" 2004 Aaron Ciechanover, Avram For the discovery of ubiquitin-mediated protein degradation Hershko, Irwin rose 2005 Yves Chauvin Robert H For the development of the metathesis method in organic synthesis Grubbs and richard r. schrock 2006 Roger D Kornberg For his studies of the molecular basis of eukaryotic transcription 2007 Gerhard Ertl For his studies of chemical processes on solid surfaces 2008 Osamu Shimomura, Martin For the discovery and development of the green fluorescent Chalfie, Roger Y. Tsien protein, GFP 2009 Venkatraman Ramakrishnan, For studies of the structure and function of the ribosome Thomas A Steitz, Ada e. 2010 Richard F. Heck, Ei-ichi Negishi, For palladium-catalyzed cross couplings in organic synthesis Akira Suzuki Dan shechtman For the discovery of quasicrystals 2012 Robert J Lefkowitz, Brian K. For studies of G-protein-coupled receptors Kobilka
2002 John B. Fenn, Koichi Tanaka, Kurt Wüthrich John B. Fenn and Koichi Tanaka "for their development of soft desorption ionisation methods for mass spectrometric analyses of biological macromolecules" and Kurt Wüthrich "for his development of nuclear magnetic resonance spectroscopy for determining the three‐dimensional structure of biological macromolecules in solution". 2003 Peter Agre, Roderick MacKinnon to Peter Agre "for the discovery of water channels" and with one half to Roderick MacKinnon "for structural and mechanistic studies of ion channels". 2004 Aaron Ciechanover, Avram Hershko, Irwin Rose For the discovery of ubiquitin‐mediated protein degradation". 2005 Yves Chauvin, Robert H. Grubbs and Richard R. Schrock For the development of the metathesis method in organic synthesis 2006 Roger D. Kornberg For his studies of the molecular basis of eukaryotic transcription 2007 Gerhard Ertl For his studies of chemical processes on solid surfaces 2008 Osamu Shimomura, Martin Chalfie, Roger Y. Tsien For the discovery and development of the green fluorescent protein, GFP 2009 Venkatraman Ramakrishnan, Thomas A. Steitz, Ada E. Yonath For studies of the structure and function of the ribosome 2010 Richard F. Heck, Ei‐ichi Negishi, Akira Suzuki For palladium‐catalyzed cross couplings in organic synthesis 2011 Dan Shechtman For the discovery of quasicrystals 2012 Robert J. Lefkowitz, Brian K. Kobilka For studies of G‐protein‐coupled receptors
i(n /ll THE HUMAN D i1 1(:: 112n GENOME 78910112 上世纪90年代,科学家历经10年花费30亿美元完成人类第一张基因草图
上世纪90年代，科学家历经10年花费30亿美元完成人类第一张基因草图
Same genome Different Proteome 幼蟲期 成期 期 蝴蝶一生具有四个明显不同的发育阶段:(1)卵期(胚胎时期);(2)幼 虫期(生长时期);(3)蛹期(转变时期);(4)成虫期(有性时期)
Same Genome Different Proteome 蝴蝶一生具有四个明显不同的发育阶段：（1）卵期（胚胎时期）；（2）幼 虫期（生长时期）；（3）蛹期（转变时期）；（4）成虫期（有性时期）
蛋白质组学在转化医学中处于核心的地位 美国NH2007年公布:转换医学作为新世纪医学研究的主要目标 转化医学面临的挑战 转化医学的目标 生物标志物的革新 有效的诊断和预后 蛋白质组学 致病机理的系统描绘 >准确认药物靶标 准确评价疗效 活性和毒性的表征 病人间的个体差异 个性化医疗的应用 Zerhouni ea. director of nih 2007, publication in clinical pharmacology and therapeutics
蛋白质组学在转化医学中处于核心的地位 蛋白质组学 生物标志物的革新 致病机理的系统描绘 准确评价疗效 病人间的个体差异 转化医学面临的挑战 有效的诊断和预后 准确确认药物靶标 活性和毒性的表征 个性化医疗的应用 转化医学的目标 Zerhouni EA, Director of NIH, 2007, publication in clinical pharmacology and therapeutics 美国NIH 2007年公布:转换医学作为新世纪医学研究的主要目标