浙医一院 Peptic Ulcer Chaohui Yu vch623 asina.co13957161659
Peptic Ulcer Chaohui Yu ych623@sina.com 13957161659
浙医一院 Suggested readings >消化性溃疡,内科学第二版人民卫生出版 社,434-445 >Acid peptic disease, Cecil medcine, 24t edition. 886-895 >Peptic ulcer disease, Lancet, 2009: 374 1449-1461 Helicobacter pylori infection, N Engl J Med2010:363:1597-1604
Suggested readings ➢消化性溃疡,内科学第二版,人民卫生出版 社,434-445 ➢Acid peptic disease, Cecil medcine,24th edition,886-895 ➢Peptic ulcer disease, Lancet, 2009; 374: 1449-1461 ➢Helicobacter pylori infection, N Engl J Med,2010;363;1597-1604
The self-digestion of GI mucosa 浙医 caused by gastric acid and pepsin The rate is 10%/ in population
The self-digestion of GI mucosa caused by gastric acid and pepsin The rate is 10% in population
Why does the ulcer happen? 浙医一院 normal defense Bicarbonate gastric mucosa mucous cells Acid, pepsine H H HCO parietal cell pH 6- Lcus laver G cell ecl cell chief cell ella ce GASTRIC GLAND mucosa
Why does the ulcer happen?- normal defense Acid, pepsine epithelial cell submucosa mucus layer Bicarbonate
Defensive barrier of gastric and duodenal mucosa mucus barrier mucosal barrier physical defense chemical counteraction quick refreshment of epithelial cell abundant circulation of blood HCO, nutrition factor: pgelege intercellular tight junction abundant submucosal blood vessel HCO, counteracts h+
Defensive barrier of gastric and duodenal mucosa mucus barrier physical defense chemical counteraction mucosal barrier quick refreshment of epithelial cell abundant circulation of blood nutrition factor: PGE1,EGF intercellular tight junction abundant submucosal blood vessel HCO3 - counteracts H+