The second principle is not 浙医一院 obvious and may seem counterintuitive The spinal fluid is produced at a constant rate(15-20 mL/hr) largely by the choroid plexus of the ventricles by an energy- dependent, physicochemical pI rocess
The second principle is not obvious and may seem counterintuitive: The spinal fluid is produced at a constant rate (∼15-20 mL/hr) largely by the choroid plexus of the ventricles by an energydependent, physicochemical process
浙一 The third basic principle. The cerebral blood flow(CBF) normally varies over a wide range (30-100 mL per 100g brain tissue per minute), depending on metabolic demand from neuronal activity within a particular area of the brain
The third basic principle: The cerebral blood flow (CBF) normally varies over a wide range (30-100 mL per 100 g brain tissue per minute), depending on metabolic demand from neuronal activity within a particular area of the brain
浙医一院 For any brain region CBF=Cerebral perfusion pressure/ Cerebral vascular resistance
For any brain region CBF=Cerebral perfusion pressure/ Cerebral vascular resistance
浙医一院 The fourth principle Injured tissue swells, making obvious the potential for a cascading injury by a vicious cycle. If the stage of compensation mentioned earlier, even with therapy, is exceeded and ICP is elevated high enough by whatever mechanism so that cerebral perfusion pressure(CPP) declines. cbf can decline to levels where tissue InJury occurs
The fourth principle: Injured tissue swells, making obvious the potential for a cascading injury by a vicious cycle. If the stage of compensation mentioned earlier, even with therapy, is exceeded and ICP is elevated high enough by whatever mechanism so that cerebral perfusion pressure (CPP) declines, CBF can decline to levels where tissue injury occurs
The vicious cycle. CPP. cerebral perfusion 浙医一院 pressure; ICP, intracranial pressure ICP CPP Infarction Edema
Edema Infarction ICP CPP The vicious cycle. CPP, cerebral perfusion pressure; ICP, intracranial pressure