Hepatic Cirrhosis Professor Wang Ji-yao Department of Internal Medicine Division of Gastroenterology, Zhongshan hospital, Fu Dan university
Hepatic Cirrhosis Professor Wang Ji-yao Department of Internal Medicine Division of Gastroenterology, Zhongshan hospital , Fu Dan university
Citthosis---definition chronic, progressed. diffuse hepatocellular injury fibrosis nodular regeneration ncidence: 17/100000/y Age: 20-50 yr
Cirrhosis---definition chronic, progressed, diffuse hepatocellular injury fibrosis nodular regeneration Incidence: 17/100000/y Age: 20-50 yr
Hepatic cirrhosis Etiology Diffuse, chronic liver injury Hepato-cellular Formation of regenerative necrosis, collapse of diffuse fibrous septa nodules formation 》 hepatic lobules Liver function Injury, Portal hypertension Complations: Upper GI Bleeding, Hepatic coma, infections, primary liver cancer, Functional renal failure
Hepatic cirrhosis 》 Etiology Liver function Injury,Portal hypertension Diffuse, chronic liver injury Hepato-cellular necrosis, collapse of hepatic lobules regenerative nodules formation Formation of diffuse fibrous septa Complations: Upper GI Bleeding, Hepatic coma, infections, primary liver cancer, Functional renal failure
Etiology of cirrhosis) 1 Chronic viral hepatitis(慢性病毒性肝炎 HBV,HCV,HBV+HDV 2 Long-term alcoholism(慢性酒精中毒) [80g/d,10y 13. Prolonged cholestasis(长期胆汁郁积, intra-and extra-hepatic: primary biliary cirrhosis, PBCI /[secondary biliary cirrhosis] 4. Drugs and toxins(药物和毒物) Itoxic hepatitis---chronic active hepatitis-- cirrhosis 5 Nonalcoholic steatohepatitis(NASH(非酒精性 脂肪性肝炎)
1.Chronic viral hepatitis (慢性病毒性肝炎): [HBV,HCV,HBV+HDV] 2. Long-term alcoholism(慢性酒精中毒) [80g/d, 10 yr.] 3. Prolonged cholestasis(长期胆汁郁积), intra-and extra-hepatic:[primary biliary cirrhosis, PBC] /[secondary biliary cirrhosis] 4. Drugs and toxins(药物和毒物) [toxic hepatitis---chronic active hepatitis--- cirrhosis] 5. Nonalcoholic steatohepatitis (NASH)(非酒精性 脂肪性肝炎) Etiology of cirrhosis(I)
Etiology of cirrhosis(II) 6. Hepatic venous outflow obstruction(肝血液循环 障碍) veno-occlusive disease, Budd-Chiari syndrome, constrictive pericarditis 7. Metabolic disorders(遗传代谢性疾病) hemochromatosis(血色病); Wilson' s disease(肝豆状核变性); 8 Autoimmune hepatitis(AH(自身免疫性肝炎) 9 Schistosomiasis(血吸虫病) 10. Cryptogenic(隐原性) 11. Mixed alcohol+virus. HBV+HCV, HBV+schistosomiasis
Etiology of cirrhosis(II) 6. Hepatic venous outflow obstruction(肝血液循环 障碍) veno-occlusive disease, Budd-Chiari syndrome, constrictive pericarditis 7. Metabolic disorders (遗传代谢性疾病) hemochromatosis(血色病);Wilson‘s disease(肝豆状核变性); 8. Autoimmune hepatitis (AIH)(自身免疫性肝炎) 9. Schistosomiasis (血吸虫病) 10. Cryptogenic (隐原性) 11. Mixed: alcohol+virus , HBV+HCV, HBV+schistosomiasis