Tuberculous Meningitis CHCUMS CHCUMS DIVISION OF INFECTIOUS DISEASE AND GASTROENTEROLOGY
1 Tuberculous Meningitis CHCUMS DIVISION OF INFECTIOUS DISEASE AND GASTROENTEROLOGY
EPIDEMIOLOGY TBM Tuberculous Meningitis (TBM) The younger the children,the more readily to develop TBM. 60%in Children aged 1-3 years ◆Death rate:15-30% 2
2 EPIDEMIOLOGY - TBM Tuberculous Meningitis (TBM) ◆ The younger the children, the more readily to develop TBM. ◆ 60% in Children aged 1-3 years ◆ Death rate: 15-30%
TBM (Tuberculous meningitis) TBM is the most serious complication of tuberculosis in children and is usually fatal without treatment. TBM always be a part of systemic disseminated tuberculosis. TBM often occurs within 1 year of initial infection,especially in the first 2 to 6 months of infection. 3
3 TBM (Tuberculous meningitis) ◆ TBM is the most serious complication of tuberculosis in children and is usually fatal without treatment. ◆ TBM always be a part of systemic disseminated tuberculosis. ◆ TBM often occurs within 1 year of initial infection, especially in the first 2 to 6 months of infection
PATHOPHYSIOLOGY Primary Bacteremia Complex Brain →® Tuberculous Bone Bacil Lung Kidney Miliary TB Meningitis Subarachnoid Space Trauma/Diseases measles,pertussis Tuberculomas Brain or Spinal Cord PerenchymaRo
4 Tuberculous Bacilli Primary Complex Bacteremia Rich Foci Subarachnoid Space Brain or Spinal Cord Perenchyma Tuberculomas Meningitis PATHOPHYSIOLOGY Trauma/Diseases measles, pertussis Miliary TB
PATHOLOGICAL EFFECTS Meninges ◆ Diffuse Hyperemia ◆ Edema Inflammatory Exudates Conformation of Tubercles 5
5 PATHOLOGICAL EFFECTS Meninges ◆ Diffuse Hyperemia ◆ Edema ◆ Inflammatory Exudates ◆ Conformation of Tubercles