Pathogenesis Affects each tissue Accumulation of glycosaminoglycans(hyaluronic acid) Not to excessive synthesis t But decreased destrution Increased capillary permeability Interstitial edema Skin ◆正 eart muscle t Striated muscle
Pathogenesis Affects each tissue Accumulation of glycosaminoglycans (hyaluronic acid) Not to excessive synthesis But decreased destrution Increased capillary permeability Interstitial edema Skin Heart muscle Striated muscle
Clinical features
Clinical Features
Adults Symptoms t Easy fatigability t Coldness Weight gain Constipation t Menstrual irregularities Signs Cool, rough, dry skin t Puffy face and hands t Hoarse and husky voice t slow reflexes t Yellowish color skin
Adults Symptoms Easy fatigability Coldness Weight gain Constipation Menstrual irregularities Signs Cool, rough, dry skin Puffy face and hands Hoarse and husky voice Slow reflexes Yellowish color skin
Clinical features Cardiovascular signs t Impaired myocardium contraction t bradycardia t Diminished cardiac output t ECG: low voltage of QRS, P, t waves t Pericardial effusion Coronary artery disease Cardiac angina(Replacement therapy aggravate
Clinical Features Cardiovascular signs Impaired myocardium contraction Bradycardia Diminished cardiac output ECG: low voltage of QRS, P, T waves Pericardial effusion Coronary artery disease Cardiac angina(Replacement therapy aggravate )