Leukemia(自血病 湖毅( Xie yi Dep Hematology, Huashan Hospital
2021/1/21 xie Yi,Hua Shan Hospital 1 Leukemia (白血病) 谢毅（Xie yi） Dep.Hematology，Huashan Hospital
Concept of leukemia Definition It is the results of the tumor proliferation of heamotopoietic stem cells.(造血干细胞) Leukemia is a malignant blood disorder. (not solid tumor) 2021/1/21 xie Yi, Hua Shan Hospital
2021/1/21 xie Yi,Hua Shan Hospital 2 Concept of leukemia Definition It is the results of the tumor proliferation of heamotopoietic stem cells.（造血干细胞） Leukemia is a malignant blood disorder. (not solid tumor)
Hematopoietic stem cell reproduction HSC lymphoid HSC HSC differentiation early progenitor CFU-GEMM myeloid HSC Heamatopoietic Stem cell(Hsc) is the primary cell of Heamatopoietic system and immune system 2021/1/21 xie Yi, Hua Shan Hospital
2021/1/21 xie Yi,Hua Shan Hospital 3 Heamatopoietic stem cell reproduction HSC lymphoid HSC HSC differentiation early progenitor CFU-GEMM myeloid HSC Heamatopoietic Stem Cell (HSC) is the primary cell of Heamatopoietic system and immune system
需魔以是能坐R Multipotent stem Cell Lymphoid stem Cell Myelaid Stem cell (CFU-S) ⑨◎ pre-T Cell pre-B Cell NK cell o⊙e⑤◎ CFU-Meo CFU-Eo CFU-GM cFU吧E ③ B Lymphocyte RIBC Mast cell EosinophIl Plasma 3 CD4 CD8 ◎◎ Cell Memon B Call Monocyte Neutrophil T Lymphocytes Megacaryocyte Macrophage From Immunology A Synthesis"(Golub and Green, 1991)
Tumor proliferation of Hsc Differentiation of hsc is blocked Leukemia cells are stopped on a differentiation stage of hsC lack of the normal function Proliferation is out of control and apoptosis is inhibited Leukemia cell is cloned and accumulated in a great quantity. infiltration and metastasis 2021/1/21 xie Yi, Hua Shan Hospital 5
2021/1/21 xie Yi,Hua Shan Hospital 5 Tumor proliferation of HSC Differentiation of HSC is blocked. Leukemia cells are stopped on a differentiation stage of HSC & lack of the normal function . Proliferation is out of control and apoptosis is inhibited. Leukemia cell is cloned and accumulated in a great quantity. infiltration and metastasis