antigen extrinsic drugs--nonhomologous serum penicillin foods--xenogenic protein pathogen-specific serotypes streptococci, HBV. HCV intrinsic nucleuS (SLE) cytoplasm (ANCA) cellular membrane antigen of tumor antigen of thyroid
antigen extrinsic drugs--nonhomologous serum, penicillin foods—xenogenic protein pathogen—specific serotypes streptococci, HBV, HCV intrinsic nucleus（SLE) cytoplasm（ANCA） cellular membrane antigen of tumor antigen of thyroid
Why does cic deposit in the glomeruli? Large area of glomerular capillaries more chances to contact Net structure of CIC easy to deposit and settle down Clearance dysfunction of mesangial cells. disability of mononuclear macrophage, component or function defect of complements Decrease clearance of cic
Why does CIC deposit in the glomeruli? • Large area of glomerrular capillaries --more chances to contact • Net structure of CIC --easy to deposit and settle down • Clearance dysfunction of mesangial cells, disability of mononuclear macrophage, component or function defect of complements Decrease clearance of CIC
(B)in situ Immunocomplex 1. Native renal antigen glomerular basement membrane anti-glomerular basement membrane antibod (anti-glomerular basement membrane glomerulonephritis) 2. Antigens trapped or planted DNA+ anti-DNA antibody LUpus Nephritis)
(B)in situ Immunocomplex 1. Native renal antigen glomerular basement membrane + anti- glomerular basement membrane antibody (anti- glomerular basement membrane glomerulonephritis) 2. Antigens trapped or planted DNA+ anti-DNA antibody (Lupus Nephritis)
Balance between the deposit and clearance of ic determines the situation of the diseases Persistence of antigen Clearance dysfunction of mesangial cells disability of mononuclear macrophage component or function defect of complements IC deposit clearance
Balance between the deposit and clearance of IC determines the situation of the diseases • Persistence of antigen • Clearance dysfunction of mesangial cells • disability of mononuclear macrophage • component or function defect of complements IC deposit > clearance
B. Cell-mediated immune mechanisms minimal change glomerulopathy
B. Cell-mediated immune mechanisms minimal change glomerulopathy ?