Hemoglobinopathies 冷 Hemoglobinopathy ☆ Thalassemia
Hemoglobinopathies ❖Hemoglobinopathy ❖Thalassemia
Extracorpuscular Hemolysis Nonimmune ☆ Infectious Chemical 令 Therma1 ☆0 smotic
Extracorpuscular Hemolysis Nonimmune ❖Infectious ❖Chemical ❖Thermal ❖Osmotic
Extracorpuscular Hemolysis Immune All require antigen-antibody reactions Types of reactions dependent on RR Class of antibody cR Number spacing of antigenic sites on cell aVAilability of complement cR Environmental Temperature c& Functional status of reticuloendothelial system ☆ Manifestations c&Intravascular hemolysis cR Extravascular hemolysis
Extracorpuscular Hemolysis Immune ❖ All require antigen-antibody reactions ❖ Types of reactions dependent on: Class of Antibody Number & Spacing of antigenic sites on cell Availability of complement Environmental Temperature Functional status of reticuloendothelial system ❖ Manifestations Intravascular hemolysis Extravascular hemolysis
Extracorpuscular Hemolysis Immune 8. Antibodies combine with rbc.& either 1. Activate complement cascade, &/or 2. Opsonize rbc for immune system .o If l, if all of complement cascade is fixed to red cell, intravascular cell lysis occurs %s If 2, &/or if complement is only partially fixed macrophages recognize Fc receptor of ig &/or C3b of complement phagocytize RBC, causing extravascular rbc destruction
Extracorpuscular Hemolysis Immune ❖ Antibodies combine with RBC, & either 1. Activate complement cascade, &/or 2. Opsonize RBC for immune system ❖ If 1, if all of complement cascade is fixed to red cell, intravascular cell lysis occurs ❖ If 2, &/or if complement is only partially fixed, macrophages recognize Fc receptor of Ig &/or C3b of complement & phagocytize RBC, causing extravascular RBC destruction
Classification 令 Intravascular 令 Extravascular
Classification ❖Intravascular ❖Extravascular