Secondary metabolites "The term 'secondary metabolites'was coined by the biochemist A.Kossel in 1891 to characterize cell components that contrast with 'primary metabolites' Albrecht Kossel (1853-1927) Julius von Sachs A German (1832-1897) 1910 Nobel Prize A German by-products”1873 Justus von Liebig 1803-1873 By 1842,Liebig had published a chemical theory of metabolism
Which Form Medication Do You Like? Why How Traditional Medicine Modern Medication Why These Roots,Stems,Leaves,Flowers, Barks and Seeds Can Be Used As Medicines? 药物的发展历程一树皮一粗提取物一单体一制剂一合成衍生物
天然药物化学 Chemistry of Natural Medicines 用化学方法研究天然药物中的化学物质及其问题的一 门学科，称为“天然药物化学” Desiring to describe and understand living organisms at the molecular level
天然药物化学 1)原植物 3)单体化合物 ● 精准医药学 HO 0 CH CH3 2)粗提物
Nature's Pharmaceuticals Morphine (Opium) 1806-Serturner Emetine (lpecacuanha) 1817-Pelletier Magendie Colchicine (Autumn crocus 1819-Pelletier Caventou Colchicum) Quinine (Cinchona bark) 1820-Pelletier Caventou Robiquet Caffeine (Coffee beans】 1821-Runge Atropine (Belladonna) 1833-Geiger Hess Papaverine 1850-E.Merck (Opium) Cocaine (Coca leaves) 1860-Niemann Physostigmine (Calabar beans) 1864-Jobst Hess Pylocarpine (Pylocarpus shrub) 1875-Gerrard Ardy CH3 Ephedrine (Ephedra) 1887-Nagai CH3 Arecoline (Areca nut) 1888-1891-Jahns