Metabolism Vitamin a acetate is hydrolyzed by enzymes into vitamin a and further is oxidized to retinal and retinoic acid. finally the conjugates of retinoic acid with glycuronic acid is excreted in bile or urine OH [O] so [o]
Metabolism • Vitamin A acetate is hydrolyzed by enzymes into vitamin A and further is oxidized to retinal and retinoic acid. Finally the conjugates of retinoic acid with glycuronic acid is excreted in bile or urine
Vitamin A analogs Vitamin a acid: it mainly influences skeletal growth and metabolism of epithelial tissue.It has better effect on prevention and cure of canner The compound is a choice drug for treatment of acute promyelocytic leukemia(aPl) H3C CH CH CH3 OH CH
Vitamin A analogs • Vitamin A acid: it mainly influences skeletal growth and metabolism of epithelial tissue. It has better effect on prevention and cure of canner. • The compound is a choice drug for treatment of acute promyelocytic leukemia (APL). H3C CH3 CH3 O CH3 CH3 OH
Vitamin d In 1922, vitamin d was found in fish liver oil In 1930, vitamin D, ergocalciferol) was isolated In 1932, vitamin D3 cholecalciferol) was isolated only difference between two vitamins is that there are a methyl group and a double bond on side chain of vitamin D2
Vitamin D • In 1922, vitamin D wasfound in fish liver oil. • In 1930, vitamin D2 (ergocalciferol) wasisolated. • In 1932, vitamin D3 (cholecalciferol) wasisolated. • Only difference between two vitamins is that there are a methyl group and a double bond on side chain of vitamin D2
Vitamin d (3B,5Z77E-9, 10-Seco-cholesta-5,7, 10 (19) -trien-3B-ol There is a conjugated triene system in the structure in which there are a hydroxy group at C-3 on a ring, a methenyl group at c-10
Vitamin D3 • (3β,5Z,7E)-9,10-Seco-cholesta-5,7,10(19)-trien-3β- ol • There is a conjugated triene system in the structure in which there are a hydroxy group at C-3 on A ring, a methenyl group at C-10. HO H