河北医科大学药学院 《彩响人羹历吏进程的100名人排行梅》Fleming列第45位 1964 Nobel Prize in Chemistry 体王国之花 1910-1994 C CLE 提取分离纯化的重要性 的什么emg漫有得到青素？“神青药物”应平10年丹 “抗生素”之父：Selman A.Vaksman The Story of Streptomycin TIME K.A.Folkers deter 天然药物化学教研室史清文教授
河北医科大学药学院 天然药物化学教研室史清文教授 6 151 It is now known that the target of the penicillins are the penicillin binding proteins transpeptidases . 《影响人类历史进程的100名人排行榜》Fleming列第45位 152 1964 Nobel Prize in Chemistry 晶体王国之花 Penicillin G Dorothy Crowfoot Hodgkin X-ray 和生物小分子结构分析 X-ray 和Dorothy Hodgkin (1910 - 1994) Penicillium chrysogeum 1945 Nobel Prize in Medicine Google commemorated Hodgkin's 104th birthday，May 12, 2014 Sir Robert Robinson did not like the b-lactam structure because this would be unstable, unlike penicillin. They were taken aback when a young woman... John W. Cornforth said “If penicillin turns out to have the b-lactam structure I shall give up chemistry and grow mushrooms.” He did not keep his threat but later received a Nobel prize for his enzyme work 30 years later. 提取分离纯化的重要性 Alexander Fleming 1881 - 1955 Ernst Chain 1906-1979 为什么Fleming没有得到青霉素？“神奇药物”应该提早10年问世？ Waksman 155 isolated it in 1942-3 and received Nobel Prize in 1952. K. A. Folkers determinde its structure in 1948. 链霉素是第一个氨基糖苷类抗生素，是第一个用于肺结核治疗的 药物，结核相当于现在的癌症，它发现改变了现代医学的进程。 Streptomycin “土壤之人” S. A. Waksman Albert Schatz O O OH O O OH HO HO HO HO OH OHC NH NH2 HN HN H2N NH NHMe “抗生素”之父: Selman A. Waksman 156 Streptomyces griseus O O OH O O OH HO HO HO HO OH OHC NH NH2 HN HN H2N NH NHMe The Story of Streptomycin The first of a class of drugs called aminoglycosides to be discovered. It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system
河北医科大学药学院 美伐他汀一洛伐他汀一利比妥 Insulin-A Storytelling Molecule 制茜历史上辅鲁量好的茜华 Insulin:A Miracle Drug Insulin-'Mechanical Cure Elirabeth Hughes Gomsert (1907-1981) and e you Insulin-"the Most Important Drug" The Discovery of Insulin and Novo Nordisk in the Company's History eatat 天然药物化学教研室史清文教授
河北医科大学药学院 天然药物化学教研室史清文教授 7 遠藤 章 博士 Lasker Award 2008 美伐他汀—洛伐他汀—利比妥 Mevastatin 1976 Jap Lovastatin 1978 1987 130 亿美元 制药历史上销售最好的药物 Penicillium citrinum N CO2H HN O F HO OH Atorvastatin (Lipitor) FDA approval 1996 Bruce D. Roth Insulin-A Storytelling Molecule Frederick Banting and Charles Best with one of the first diabetic dogs to receive insulin, 1923 NP Frederick Sanger 1918-2013,1958 NP Dorothy C. Hodgkin 1910-1994, 1964 NP The human insulin protein is composed of 51 amino acids Insulin: A Miracle Drug Charles Herbert Best (1899-1978) Charles Herbert Best was the youngest of the co-discoverers of insulin, the youngest of the co-discoverers of insulin in 1921. Frederick Banting 1923 NP John J. R. Macleod 1923 NP Insulin-'Mechanical Cure' Frederick Madison Allen (1879–1964) Dr. Diabetes Elizabeth Hughes Gossett (1907-1981) Elizabeth H. Gossett, the daughter of U.S. politician Charles Evans Hughes, was the first American, and one of the first people in the world, treated with insulin for type 1 diabetes. She received over 42,000 insulin shots before she died in 1981. She had two daughters and a son. Elizabeth-The second cilinic test-a 15-year-old girl with severe diabetes and the making of a medical miracle Insulin-"the Most Important Drug" in the Company's History Eli Lilly and Company-Colonel Eli Lilly, founded in 1876. Clowes proposed a collaboration with the researchers in December 1921. In 1923, Lilly began selling Iletin (Insulin, Lilly).Insulin, "the most important drug" in the company's history, did "more than any other" to make Lilly "one of the major pharmaceutical manufacturers in the world." Josiah K. Lilly, Sr. (1861–1948) 1898- Second company president Eli Lilly (1885–1977) 1932- Third president of Eli Lilly and Company George Henry Alexander Clowes (1877-1958) First research director Portrait of a Collector The Discovery of Insulin and Novo Nordisk August Krogh 1920 NP August and Marie Krogh (1874-1949) (1874-1943) The Founders of Novo Nordis 诺和诺德公司（Novo Nordisk）是一家致力于人类健康、以先进的生 物技术造福患者、医生和社会的世界领先生物制药公司。诺和诺德公司在 行业内拥有最为广泛的糖尿病治疗产品，包括最先进的胰岛素给药系统产 品，80多年来一直是世界糖尿病研究和药物开发领域的主导