Normal hemostasis and coagulation 2. platelet (1) adhesion to subendothelial connective tissue by GPi b、WF (2) aggregation formation of platelet thrombus by gPllb/Ⅲa (3 release phosphatide-Arachidonic Acid -TXA2 further platelet activation and adhesion violent vessel spasm
Normal hemostasis and coagulation 2. platelet： （1）adhesion： to subendothelial connective tissue by GPⅠb、vWF （2）aggregation ： formation of platelet thrombus by GPⅡb/Ⅲa （3）release： phosphatide-Arachidonic Acid -TXA2 further platelet activation and adhesion violent vessel spasm
Normal hemostasis and coagulation 3. coagulation: (1)Rearrangement of platelet membrane phosphatidate-PF3 (2) Tissue injury- TF release (3) Subendothelial| connective tissueⅫ-Ⅻa triggering intrinsic and extrinsic pathway- white thrombus-red thrombus
Normal hemostasis and coagulation 3. coagulation: （1） Rearrangement of platelet membrane phosphatidate-PF3 （2） Tissue injury- TF release （3） Subendothelial connective tissue-Ⅻ-Ⅻa triggering intrinsic and extrinsic pathwaywhite thrombus-red thrombus
Normal hemostasis and coagulation coagulation 1. nature: a cascade of enzymes activation not active before activated 2. component 1.12 coagulation factor protein( exclude ca×O 11 in plasma( tissue factor) code with IV etc 2. PK R 3. HMWK
Normal hemostasis and coagulation • coagulation： 1. nature: a cascade of enzymes activation not active before activated 2. component: 1. 12 coagulation factor: 11 in plasma (tissue factor) protein ( exclude Ca++ ) code with Ⅰ、Ⅱ、Ⅲ、Ⅳ etc. 2. PK 3. HMWK
Normal hemostasis and coagulation 3. course (1) thromboplastin intrinsic: XI- XIXIa-iX Ia+Ⅷ山+ca+PF3 extrinsic: ll-Vll+Ca X-Xa+V+Ca+PF3 (2) thrombin: prothrombinthromboplatin+Cathrombin
Normal hemostasis and coagulation 3. course： （1）thromboplatin intrinsic: Ⅻ-Ⅻa——Ⅺ-Ⅺa-Ⅸ- Ⅸa+Ⅷ+Ca+PF3 extrinsic: III-VII+Ca Ⅹ-Ⅹa+Ⅴ+Ca+PF3 （2）thrombin：prothrombinthromboplatin+Cathrombin