Pathophysiology
Pathophysiology
Abnormalities in metabolism ● Carbohydrate: anabolism, catabolism↑ utilization Lipid anabolism, catabolism ketoplasia ● protein: anabolism, catabolism↑, glyconeogenesis
Abnormalities in metabolism ⚫ Carbohydrate ：anabolism ，catabolism、 utilization ⚫ Lipid ： anabolism ，catabolism ， ketoplasia ⚫ protein： anabolism ，catabolism ， glyconeogenesis
Insulin secretion curve normal and diabetics 1600 1400 Htype2 1200 1000 800 obese 600 →·type1 400 200 30 90 120 C⊥oc k 1me (hours
Insulin secretion curve :normal and diabetics 0 200 400 600 800 1000 1200 1400 1600 0 3 0 6 0 9 0 120 clock time(hours) insulin(μU/ml） type2 normal obese type 1
Clinical Presentation
Clinical Presentation
Natural history of type 2 DM After the diagnosis of type 2 diabetes IR constantly exists Insulin secretion ability gradually declines When fpg reachs the diagnostic criteria, insulin secretion ability has already declined by 50%0 When FPG≌7.0mmo/L,β cellinsulin secretion ability When fpg≥10~1mmo/L,β- Insulin secretion ability has already neared absolute deficiency
Natural history of type 2 DM After the diagnosis of type 2 diabetes: IR constantly exists Insulin secretion ability gradually declines: When FPG reachs the diagnostic criteria，insulin secretion ability has already declined by 50% When FPG≥7.0mmol/L，-cell insulin secretion ability When FPG≥1011.0mmol/L，-C insulin secretion ability has already neared absolute deficiency