Susceptibility gene Environmental Factors/Sex hormone Helper T cell activity Hyperactivated B cell Immune complex Self antibody self antigens Multiple system involvement vasculitis
Susceptibility gene Environmental Factors Sex hormone Helper T cell activity Hyperactivated B cell Immune complex Self antibody + self antigens Multiple system involvement vasculitis
五. Pathology 1. vasculitis 2. lupus nephritis a. minimal change b. mesangial proliferative C focal segmental lesions d diffuse e, membranous f. sclerosing
五. Pathology 1. vasculitis 2. lupus nephritis a. minimal change b. mesangial proliferative c. focal segmental lesions d. diffuse e. membranous f. sclerosing
A Clinical menifestations Of sle Multiple system involvement
六.Clinical menifestations of SLE -----Multiple system involvement
1. Nonspecific symptom o fever o loss of weight o inertia
1. Nonspecific symptom ● fever ● loss of weight ● inertia
2 Skin and mucosa o skin symptoms in 80% of patients ● specIfIC features:40% malar rash discoid rash o nonspecific features 60% ● photosensitivity40% o baldness 40% o oral ulcer 60% Raynaud's phenomenon
2.Skin and mucosa ● skin symptoms in 80% of patients ● specific features: 40% malar rash discoid rash ● nonspecific features 60% ● photosensitivity 40% ● baldness 40% ● oral ulcer 60% ● Raynaud’s phenomenon