Dark ages Hypotonic Period Trisomy Period Banding era Molecular era Pardue ML, et al. Molecular hybridization of radioactive DNA to the DNA of cytological preparations. Proc. Natl Acad.Sci.UsA.1969:64:600-604 Pinkel D,et al. Cytogenetic analysis using quantitative, high-sensitivity, fluorescence hybridization. Proc. Natl Acad.Sci.uSA.1986;83:2934-2938
Molecular Era Pardue ML, et al. Molecular hybridization of radioactive DNA to the DNA of cytological preparations. Proc. Natl. Acad. Sci. USA. 1969; 64: 600 - 604 Pinkel D, et al. Cytogenetic analysis using quantitative, high-sensitivity, fluorescence hybridization. Proc. Natl. Acad. Sci. USA. 1986; 83: 2934-2938. Hypotonic Period Dark Ages Banding Era Trisomy Period
Denver System The karyotype is a photograph of all of the chromosomes of an individual cell, the term covers the number, relative sizes and structure of the chromosomes Karyotype analysis: arranging the chromosomes of a cell into a karyotype, then analysis and compare with denver system
Karyotype analysis: arranging the chromosomes of a cell into a karyotype, then analysis and compare with Denver system. Denver System The karyotype is a photograph of all of the chromosomes of an individual cell; the term covers the number, relative sizes and structure of the chromosomes
Denver System Chromosome can be distinguished by the relative sizes and the position of the centromere 13 Acrocentric Submetacentric (13,14,15,21,22,Y) Metacentric (2,4-12,17,18,X) (1,3,16,19,20)
Chromosome can be distinguished by the relative sizes and the position of the centromere. Metacentric (1, 3, 16, 19, 20) Submetacentric (2, 4-12, 17, 18, X) Acrocentric (13, 14, 15, 21, 22, Y) Denver System
Denver System 》x(晶 日y 非);2t
Denver System
Banding pattern Band: treated with chemical dves, the chromosome will appear as a series of alternate dark and light striations Banding pattern: treated with chemical dyes, 24 types of chromosomes appear its unique striations individuall
Banding Pattern Band: treated with chemical dyes, the chromosome will appear as a series of alternate dark and light striations. Banding pattern：treated with chemical dyes, 24 types of chromosomes appear its unique striations individually