Absorption of Bilirubin 1. Intake of unconjugated bilirubin by 2. Separation of albumin from bilirubin 3. Bilirubin enters the hepatic cell 4. To the microsome by y, z protein
Absorption of Bilirubin 1. Intake of unconjugated bilirubin by ? 2. Separation of albumin from bilirubin. 3. Bilirubin enters the hepatic cell. 4. To the microsome by Y,Z protein
Conjugation of Bilirubin Conjugated with glucuronate 75%, by glucuronide transferase Others 25%, conjugated with glucose, glycine Characteristic of conjugated bilirubin x Dissolvable x Nonpoisonous to biomembrane which contains phospholipid x Elimination through urine
Conjugation of Bilirubin • Conjugated with glucuronate 75%, by glucuronide transferase • Others 25%, conjugated with glucose, glycine • Characteristic of conjugated bilirubin Dissolvable Nonpoisonous to biomembrane which contains phospholipid Elimination through urine
Excretion of Bilirubin CB→→ Golgi-bile capillary bile tubule→→ bile duct-→ intestine Urobilinogen-→ fecalbilinogen-→ excretion lower ileum, colon+reabsorption portal vein→+lier-→ bilirubin-→ biles+intestine
Excretion of Bilirubin CB Golgi bile capillary bile tubule bile duct intestine Urobilinogen fecalbilinogen excretion lower ileum,colon reabsorption portal vein liver bilirubin biles intestine
Classification of Bilirubin( 1) By etiology. Hemolytic jaundice Hepatic jaundice Obstructive jaundice Congenital jaundice
Classification of Bilirubin (1) • By etiology: Hemolytic jaundice Hepatic jaundice Obstructive jaundice Congenital jaundice